ENSG00000136205


Homo sapiens

Features
Gene ID: ENSG00000136205
  
Biological name :TNS3
  
Synonyms : Q68CZ2 / tensin 3 / TNS3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p12.3
Gene start: 47275154
Gene end: 47582558
  
Corresponding Affymetrix probe sets: 217853_at (Human Genome U133 Plus 2.0 Array)   234257_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388142
Ensembl peptide - ENSP00000388318
Ensembl peptide - ENSP00000414358
Ensembl peptide - ENSP00000409415
Ensembl peptide - ENSP00000407464
Ensembl peptide - ENSP00000396914
Ensembl peptide - ENSP00000389285
Ensembl peptide - ENSP00000312143
Ensembl peptide - ENSP00000387990
NCBI entrez gene - 64759     See in Manteia.
OMIM - 606825
RefSeq - XM_017012539
RefSeq - XM_011515478
RefSeq - XM_011515479
RefSeq - XM_011515480
RefSeq - XM_011515481
RefSeq - XM_011515482
RefSeq - XM_011515483
RefSeq - XM_017012537
RefSeq - XM_017012538
RefSeq - NM_022748
RefSeq - XM_011515476
RefSeq - XM_011515477
RefSeq Peptide - NP_073585
swissprot - C9JUW5
swissprot - C9JTD0
swissprot - C9JHU5
swissprot - H7BZ64
swissprot - E9PCX8
swissprot - C9JWN9
swissprot - Q68CZ2
Ensembl - ENSG00000136205
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tns3.2ENSDARG00000031911Danio rerio
 TNS3ENSGALG00000039139Gallus gallus
 Tns3ENSMUSG00000020422Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNS1 / Q9HBL0 / tensin 1ENSG0000007930848
TNS2 / Q63HR2 / tensin 2ENSG0000011107736
TNS4 / Q8IZW8 / tensin 4ENSG0000013174618
DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6ENSG0000011667513
GAK / O14976 / cyclin G associated kinaseENSG0000017895013
PTEN / P60484 / phosphatase and tensin homologENSG000001718627
TPTE2 / Q6XPS3 / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2ENSG000001329585
TPTE / P56180 / transmembrane phosphatase with tensin homologyENSG000002743915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR033929  Tensin, phosphotyrosine-binding domain
 IPR035012  Tensin-like, SH2 domain
 IPR035892  C2 domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048286 lung alveolus development IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
MET interacts with TNS proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / reaction / complex






 

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