ENSG00000131746


Homo sapiens

Features
Gene ID: ENSG00000131746
  
Biological name :TNS4
  
Synonyms : Q8IZW8 / tensin 4 / TNS4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.2
Gene start: 40475828
Gene end: 40501597
  
Corresponding Affymetrix probe sets: 222265_at (Human Genome U133 Plus 2.0 Array)   230398_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000254051
Ensembl peptide - ENSP00000463456
NCBI entrez gene - 84951     See in Manteia.
OMIM - 608385
RefSeq - XM_017025236
RefSeq - NM_032865
RefSeq - XM_005257744
RefSeq Peptide - NP_116254
swissprot - Q8IZW8
swissprot - J3QLA4
Ensembl - ENSG00000131746
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNS4ENSGALG00000028308Gallus gallus
 Tns4ENSMUSG00000017607Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNS1 / Q9HBL0 / tensin 1ENSG0000007930836
TNS3 / Q68CZ2 / tensin 3ENSG0000013620535
TNS2 / Q63HR2 / tensin 2ENSG0000011107731
GAK / O14976 / cyclin G associated kinaseENSG0000017895012
DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6ENSG0000011667512
PTEN / P60484 / phosphatase and tensin homologENSG000001718625
TPTE2 / Q6XPS3 / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2ENSG000001329583
TPTE / P56180 / transmembrane phosphatase with tensin homologyENSG000002743912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR033929  Tensin, phosphotyrosine-binding domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008104 protein localization IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
MET interacts with TNS proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction






 

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