ENSG00000111077


Homo sapiens

Features
Gene ID: ENSG00000111077
  
Biological name :TNS2
  
Synonyms : Q63HR2 / tensin 2 / TNS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53046969
Gene end: 53064372
  
Corresponding Affymetrix probe sets: 212494_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449363
Ensembl peptide - ENSP00000449361
Ensembl peptide - ENSP00000473388
Ensembl peptide - ENSP00000319684
Ensembl peptide - ENSP00000319756
Ensembl peptide - ENSP00000369232
Ensembl peptide - ENSP00000447021
Ensembl peptide - ENSP00000449165
NCBI entrez gene - 23371     See in Manteia.
OMIM - 607717
RefSeq - XM_017019089
RefSeq - NM_015319
RefSeq - NM_170754
RefSeq - NM_198316
RefSeq - XM_006719302
RefSeq - XM_006719303
RefSeq - XM_011538079
RefSeq - XM_017019088
RefSeq Peptide - NP_938072
RefSeq Peptide - NP_056134
RefSeq Peptide - NP_736610
swissprot - Q63HR2
swissprot - R4GMX1
swissprot - A0A024RB48
swissprot - F8VV64
swissprot - H0YID7
Ensembl - ENSG00000111077
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tns2aENSDARG00000076292Danio rerio
 tns2bENSDARG00000068397Danio rerio
 Tns2ENSMUSG00000037003Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNS1 / Q9HBL0 / tensin 1ENSG0000007930838
TNS3 / Q68CZ2 / tensin 3ENSG0000013620537
TNS4 / Q8IZW8 / tensin 4ENSG0000013174616
GAK / O14976 / cyclin G associated kinaseENSG0000017895014
DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6ENSG0000011667512
PTEN / P60484 / phosphatase and tensin homologENSG000001718627
TPTE2 / Q6XPS3 / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2ENSG000001329586
TPTE / P56180 / transmembrane phosphatase with tensin homologyENSG000002743916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR033929  Tensin, phosphotyrosine-binding domain
 IPR035012  Tensin-like, SH2 domain
 IPR035892  C2 domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0019725 cellular homeostasis IEA
 biological_processGO:0032963 collagen metabolic process IEA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048871 multicellular organismal homeostasis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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