ENSG00000274391


Homo sapiens

Features
Gene ID: ENSG00000274391
  
Biological name :TPTE
  
Synonyms : P56180 / TPTE / transmembrane phosphatase with tensin homology
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: p11.2
Gene start: 10521553
Gene end: 10606140
  
Corresponding Affymetrix probe sets: 220205_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482040
Ensembl peptide - ENSP00000483087
Ensembl peptide - ENSP00000484064
Ensembl peptide - ENSP00000484403
Ensembl peptide - ENSP00000482488
NCBI entrez gene - 7179     See in Manteia.
OMIM - 604336
RefSeq - NM_001290224
RefSeq - NM_199259
RefSeq - NM_199260
RefSeq - NM_199261
RefSeq Peptide - NP_001277153
RefSeq Peptide - NP_954868
RefSeq Peptide - NP_954869
RefSeq Peptide - NP_954870
swissprot - P56180
swissprot - A0A087X1C4
Ensembl - ENSG00000274391
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpteENSDARG00000056985Danio rerio
 ENSGALG00000017031Gallus gallus
 TpteENSMUSG00000031481Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPTE2 / Q6XPS3 / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2ENSG0000013295883
PTEN / P60484 / phosphatase and tensin homologENSG0000017186223
GAK / O14976 / cyclin G associated kinaseENSG0000017895020
TNS1 / Q9HBL0 / tensin 1ENSG0000007930816
TNS2 / Q63HR2 / tensin 2ENSG0000011107716
DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6ENSG0000011667515
TNS3 / Q68CZ2 / tensin 3ENSG0000013620514
TNS4 / Q8IZW8 / tensin 4ENSG000001317463


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity TAS
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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