ENSG00000132958


Homo sapiens

Features
Gene ID: ENSG00000132958
  
Biological name :TPTE2
  
Synonyms : Q6XPS3 / TPTE2 / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q12.11
Gene start: 19422877
Gene end: 19536762
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSP00000432402
Ensembl peptide - ENSP00000382974
Ensembl peptide - ENSP00000383089
Ensembl peptide - ENSP00000255310
Ensembl peptide - ENSP00000372438
Ensembl peptide - ENSP00000375098
NCBI entrez gene - 93492     See in Manteia.
OMIM - 606791
RefSeq - NM_130785
RefSeq - NM_001141968
RefSeq - NM_199254
RefSeq Peptide - NP_570141
RefSeq Peptide - NP_001135440
RefSeq Peptide - NP_954863
swissprot - Q6XPS3
swissprot - G3V171
Ensembl - ENSG00000132958
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpteENSDARG00000056985Danio rerio
 ENSGALG00000017031Gallus gallus
 TpteENSMUSG00000031481Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPTE / P56180 / transmembrane phosphatase with tensin homologyENSG0000027439188
PTEN / P60484 / phosphatase and tensin homologENSG0000017186225
GAK / O14976 / cyclin G associated kinaseENSG0000017895022
TNS2 / Q63HR2 / tensin 2ENSG0000011107717
DNAJC6 / O75061 / DnaJ heat shock protein family (Hsp40) member C6ENSG0000011667517
TNS1 / Q9HBL0 / tensin 1ENSG0000007930817
TNS3 / Q68CZ2 / tensin 3ENSG0000013620515
TNS4 / Q8IZW8 / tensin 4ENSG000001317464


Protein motifs (from Interpro)
Interpro ID Name
 IPR000340  Dual specificity phosphatase, catalytic domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR016130  Protein-tyrosine phosphatase, active site
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA
 molecular_functionGO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the Golgi membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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