ENSMUSG00000028528


Mus musculus

Features
Gene ID: ENSMUSG00000028528
  
Biological name :Dnajc6
  
Synonyms : Dnajc6 / DnaJ heat shock protein family (Hsp40) member C6 / Q80TZ3
  
Possible biological names infered from orthology : O75061
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 101496648
Gene end: 101642799
  
Corresponding Affymetrix probe sets: 10506274 (MoGene1.0st)   1431215_at (Mouse Genome 430 2.0 Array)   1431216_s_at (Mouse Genome 430 2.0 Array)   1433596_at (Mouse Genome 430 2.0 Array)   1438896_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114840
Ensembl peptide - ENSMUSP00000102546
Ensembl peptide - ENSMUSP00000119542
Ensembl peptide - ENSMUSP00000044251
Ensembl peptide - ENSMUSP00000092560
Ensembl peptide - ENSMUSP00000102542
Ensembl peptide - ENSMUSP00000102543
NCBI entrez gene - 72685     See in Manteia.
MGI - MGI:1919935
RefSeq - XM_017320393
RefSeq - NM_001164583
RefSeq - NM_001164584
RefSeq - NM_001164585
RefSeq - NM_001355179
RefSeq - NM_001355180
RefSeq - NM_198412
RefSeq - XM_006503421
RefSeq Peptide - NP_001158055
RefSeq Peptide - NP_001158056
RefSeq Peptide - NP_001342108
RefSeq Peptide - NP_001342109
RefSeq Peptide - NP_940804
RefSeq Peptide - NP_001158057
swissprot - B1B0B8
swissprot - Q80TZ3
swissprot - B1B0B7
Ensembl - ENSMUSG00000028528
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnajc6ENSDARG00000079891Danio rerio
 DNAJC6ENSGALG00000011041Gallus gallus
 DNAJC6ENSG00000116675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gak / cyclin-G-associated kinase isoform 3 / O14976* / cyclin G associated kinase*ENSMUSG0000006223444
Tns3 / Q5SSZ5 / Tensin-3 / Q68CZ2*ENSMUSG0000002042220
Tns1 / tensin 1 / Q9HBL0*ENSMUSG0000005532219
Tns2 / Q8CGB6 / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA. / Q63HR2* / tensin 2*ENSMUSG0000003700318
Tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSMUSG000000314819
Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*ENSMUSG000000176078
Pten / O08586 / phosphatase and tensin homolog / P60484*ENSMUSG000000136638


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR035892  C2 domain superfamily
 IPR036869  Chaperone J-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0016191 synaptic vesicle uncoating IMP
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0072318 clathrin coat disassembly IMP
 biological_processGO:2000369 regulation of clathrin-dependent endocytosis IMP
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0031982 vesicle IBA
 cellular_componentGO:0045202 synapse IMP
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dag1tm3Kcam/Dag1tm3Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dnajc6tm1Legr/Dnajc6+
Genetic Background: B6.129-Dnajc6tm1Legr

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dag1tm3Kcam/Dag1tm3Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dag1tm3Kcam/Dag1tm3Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008976 delayed female fertility "ability of a female organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dag1tm3Kcam/Dag1tm3Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Dag1tm3Kcam/Dag1tm3Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dnajc6tm1Legr/Dnajc6+
Genetic Background: B6.129-Dnajc6tm1Legr

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dag1tm3Kcam/Dag1tm3Kcam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Dnajc6tm1Legr/Dnajc6+
Genetic Background: B6.129-Dnajc6tm1Legr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / complex






 

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