ENSMUSG00000055322


Mus musculus

Features
Gene ID: ENSMUSG00000055322
  
Biological name :Tns1
  
Synonyms : tensin 1 / Tns1
  
Possible biological names infered from orthology : Q9HBL0
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 73910231
Gene end: 74124449
  
Corresponding Affymetrix probe sets: 10355514 (MoGene1.0st)   10355528 (MoGene1.0st)   10355530 (MoGene1.0st)   10355532 (MoGene1.0st)   10355534 (MoGene1.0st)   10355536 (MoGene1.0st)   1419283_s_at (Mouse Genome 430 2.0 Array)   1428650_at (Mouse Genome 430 2.0 Array)   1449405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139616
Ensembl peptide - ENSMUSP00000127715
Ensembl peptide - ENSMUSP00000139721
Ensembl peptide - ENSMUSP00000148638
Ensembl peptide - ENSMUSP00000140991
Ensembl peptide - ENSMUSP00000140878
Ensembl peptide - ENSMUSP00000140837
Ensembl peptide - ENSMUSP00000140771
Ensembl peptide - ENSMUSP00000140448
Ensembl peptide - ENSMUSP00000140317
Ensembl peptide - ENSMUSP00000140254
Ensembl peptide - ENSMUSP00000140094
Ensembl peptide - ENSMUSP00000139844
NCBI entrez gene - 21961     See in Manteia.
MGI - MGI:104552
RefSeq - XM_017319866
RefSeq - XM_006495881
RefSeq - XM_006495882
RefSeq - XM_011238476
RefSeq - XM_011238477
RefSeq - XM_017319847
RefSeq - XM_017319848
RefSeq - XM_017319853
RefSeq - XM_017319856
RefSeq - XM_017319858
RefSeq - XM_017319859
RefSeq - XM_017319860
RefSeq - XM_017319862
RefSeq - XM_017319863
RefSeq - XM_017319864
RefSeq - XM_017319865
RefSeq - NM_001289895
RefSeq - NM_027884
RefSeq - XM_006495867
RefSeq - XM_006495871
RefSeq - XM_006495872
RefSeq - XM_006495873
RefSeq - XM_006495874
RefSeq - XM_006495875
RefSeq - XM_006495877
RefSeq - XM_006495878
RefSeq - XM_006495879
RefSeq - XM_006495880
RefSeq Peptide - NP_001276824
RefSeq Peptide - NP_082160
swissprot - A0A087WSC8
swissprot - A0A087WS32
swissprot - A0A087WRZ8
swissprot - A0A087WRU0
swissprot - A0A087WR29
swissprot - E9Q0S6
swissprot - A0A087WQM0
swissprot - A0A087WQ94
swissprot - A0A087WPC7
swissprot - Q9DBT6
swissprot - A0A087WP40
swissprot - A0A087WQS0
swissprot - A0A1D5RM59
Ensembl - ENSMUSG00000055322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tns1aENSDARG00000078842Danio rerio
 tns1bENSDARG00000020845Danio rerio
 TNS1ENSGALG00000041013Gallus gallus
 TNS1ENSG00000079308Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tns3 / Q5SSZ5 / Tensin-3 / Q68CZ2*ENSMUSG0000002042235
Tns2 / Q8CGB6 / Mus musculus tensin 2 (Tns2), transcript variant 2, mRNA. / Q63HR2* / tensin 2*ENSMUSG0000003700330
Tns4 / Q8BZ33 / Tensin-4 / Q8IZW8*ENSMUSG0000001760713
Gak / cyclin-G-associated kinase isoform 3 / O14976* / cyclin G associated kinase*ENSMUSG0000006223412
Dnajc6 / Q80TZ3 / DnaJ heat shock protein family (Hsp40) member C6 / O75061*ENSMUSG0000002852810
Pten / O08586 / phosphatase and tensin homolog / P60484*ENSMUSG000000136636
Tpte / transmembrane phosphatase with tensin homology / TPTE2* / Q6XPS3* / P56180* / transmembrane phosphoinositide 3-phosphatase and tensin homolog 2*ENSMUSG000000314816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR003595  Protein-tyrosine phosphatase, catalytic
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR014020  Tensin phosphatase, C2 domain
 IPR029021  Protein-tyrosine phosphatase-like
 IPR029023  Tensin-type phosphatase domain
 IPR033929  Tensin, phosphotyrosine-binding domain
 IPR035012  Tensin-like, SH2 domain
 IPR035892  C2 domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007044 cell-substrate junction assembly IMP
 biological_processGO:0010761 fibroblast migration IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0030055 cell-substrate junction IDA
 molecular_functionGO:0003779 actin binding TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: a/a,Tyrc/Tyrem2Ove
Genetic Background: involves: C57BL/6 * FVB

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004194 abnormal kidney pelvis morphology "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005526 decreased renal plasma flow rate "less than the normal volume of plasma passing throught the kidney per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009050 dilated proximal convoluted tubules "stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010614 abnormal mitral valve cusp morphology "any structural anomaly of the two fibrous components and associated flaps of the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Tyrc/Tyrem2Ove
Genetic Background: involves: C57BL/6 * FVB

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011534 granular kidney "a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis" [MGI:anna]
Show

Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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