ENSMUSG00000015656


Mus musculus

Features
Gene ID: ENSMUSG00000015656
  
Biological name :Hspa8
  
Synonyms : Heat shock cognate 71 kDa protein / Hspa8 / P63017
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 8 / P11142
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 40800984
Gene end: 40810087
  
Corresponding Affymetrix probe sets: 10368025 (MoGene1.0st)   10528021 (MoGene1.0st)   10584572 (MoGene1.0st)   10584576 (MoGene1.0st)   10584578 (MoGene1.0st)   10584580 (MoGene1.0st)   1420622_a_at (Mouse Genome 430 2.0 Array)   1420623_x_at (Mouse Genome 430 2.0 Array)   1431182_at (Mouse Genome 430 2.0 Array)   1455789_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117285
Ensembl peptide - ENSMUSP00000015800
Ensembl peptide - ENSMUSP00000113722
NCBI entrez gene - 15481     See in Manteia.
MGI - MGI:105384
RefSeq - NM_031165
RefSeq Peptide - NP_112442
swissprot - D3Z5E2
swissprot - P63017
swissprot - Q504P4
Ensembl - ENSMUSG00000015656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa8ENSDARG00000068992Danio rerio
 si:dkey-4p15.3ENSDARG00000037403Danio rerio
 HSPA8ENSGALG00000006512Gallus gallus
 HSPA8ENSG00000109971Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hspa2 / P17156 / Heat shock-related 70 kDa protein 2 / P54652* / heat shock protein family A (Hsp70) member 2*ENSMUSG0000005997085
P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG0000009087784
Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG0000009197184
Hspa1l / P16627 / Heat shock 70 kDa protein 1-like / P34931* / heat shock protein family A (Hsp70) member 1 like*ENSMUSG0000000703383
Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*ENSMUSG0000002686464
Hspa14 / Q99M31 / Heat shock 70 kDa protein 14 / Q0VDF9* / heat shock protein family A (Hsp70) member 14*ENSMUSG0000010986526


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006457 protein folding IDA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0042026 protein refolding IEA
 biological_processGO:0043624 cellular protein complex disassembly ISO
 biological_processGO:0044788 modulation by host of viral process IMP
 biological_processGO:0044829 positive regulation by host of viral genome replication IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IGI
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0061635 regulation of protein complex stability ISS
 biological_processGO:0061684 chaperone-mediated autophagy ISS
 biological_processGO:0061738 late endosomal microautophagy IMP
 biological_processGO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy IEA
 biological_processGO:0061741 chaperone-mediated protein transport involved in chaperone-mediated autophagy ISO
 biological_processGO:0072318 clathrin coat disassembly IGI
 biological_processGO:1902904 negative regulation of supramolecular fiber organization IEA
 biological_processGO:1904764 chaperone-mediated autophagy translocation complex disassembly ISS
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000974 Prp19 complex IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005765 lysosomal membrane ISS
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:1990836 lysosomal matrix ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042623 ATPase activity, coupled IDA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005483 Dnajb1 / Q9QYJ3 / DnaJ homolog subfamily B member 1 / P25685* / DnaJ heat shock protein family (Hsp40) member B1*  / complex
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / reaction
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / complex / reaction
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000020063 Sirt1 / Q923E4 / NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment / Q96EB6* / sirtuin 1*  / complex / reaction
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / reaction / complex
 ENSMUSG00000028410 Dnaja1 / P63037 / DnaJ homolog subfamily A member 1 / P31689* / DnaJ heat shock protein family (Hsp40) member A1*  / complex / reaction
 ENSMUSG00000031701 Dnaja2 / Q9QYJ0 / DnaJ homolog subfamily A member 2 / O60884* / DnaJ heat shock protein family (Hsp40) member A2*  / reaction / complex
 ENSMUSG00000028528 Dnajc6 / Q80TZ3 / DnaJ heat shock protein family (Hsp40) member C6 / O75061*  / complex
 ENSMUSG00000032285 Dnaja4 / Q9JMC3 / Mus musculus DnaJ heat shock protein family (Hsp40) member A4 (Dnaja4), transcript variant 1, mRNA. / Q8WW22* / DnaJ heat shock protein family (Hsp40) member A4*  / complex / reaction
 ENSMUSG00000025956 Q9CQL0 / Mettl21a / Protein N-lysine methyltransferase METTL21A / Q8WXB1* / methyltransferase like 21A*  / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction
 ENSMUSG00000024222 Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*  / complex / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / complex / reaction






 

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