ENSMUSG00000030357


Mus musculus

Features
Gene ID: ENSMUSG00000030357
  
Biological name :Fkbp4
  
Synonyms : Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
  
Possible biological names infered from orthology : FK506 binding protein 4 / Q02790
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 128429735
Gene end: 128438677
  
Corresponding Affymetrix probe sets: 10548194 (MoGene1.0st)   1416362_a_at (Mouse Genome 430 2.0 Array)   1416363_at (Mouse Genome 430 2.0 Array)   1459808_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122087
Ensembl peptide - ENSMUSP00000032508
Ensembl peptide - ENSMUSP00000119930
NCBI entrez gene - 14228     See in Manteia.
MGI - MGI:95543
RefSeq - NM_010219
RefSeq Peptide - NP_034349
swissprot - P30416
swissprot - F6S2D5
swissprot - F7CAT1
Ensembl - ENSMUSG00000030357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fkbp4ENSDARG00000008447Danio rerio
 FKBP4ENSGALG00000014331Gallus gallus
 FKBP4ENSG00000004478Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*ENSMUSG0000002422253
Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A / FKBP1C* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A*ENSMUSG0000003296612
Fkbp1b / Q9Z2I2 / Peptidyl-prolyl cis-trans isomerase FKBP1B / P68106* / FK506 binding protein 1B*ENSMUSG0000002063512
Fkbp3 / Q62446 / Peptidyl-prolyl cis-trans isomerase FKBP3 / Q00688* / FK506 binding protein 3*ENSMUSG0000002094912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR001440  Tetratricopeptide repeat 1
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR013105  Tetratricopeptide repeat 2
 IPR019734  Tetratricopeptide repeat
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type
 IPR031212  Peptidyl-prolyl cis-trans isomerase FKBP4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0006463 steroid hormone receptor complex assembly IDA
 biological_processGO:0006825 copper ion transport IEA
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0030521 androgen receptor signaling pathway IMP
 biological_processGO:0030850 prostate gland development IMP
 biological_processGO:0031111 negative regulation of microtubule polymerization or depolymerization ISS
 biological_processGO:0031115 negative regulation of microtubule polymerization IEA
 biological_processGO:0031503 protein-containing complex localization IDA
 biological_processGO:0046661 male sex differentiation IMP
 biological_processGO:0048608 reproductive structure development IMP
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0005528 FK506 binding IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0032767 copper-dependent protein binding IEA
 molecular_functionGO:0035259 glucocorticoid receptor binding IDA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IDA


Pathways (from Reactome)
Pathway description
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Fkbp4tm1Dvds/Fkbp4tm1Dvds
Genetic Background: either: (involves: CD-1) or (involves: 129X1/SvJ * C57BL/6)

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttc7fsn/Ttc7fsn-Jic
Genetic Background: involves: A/J * BALB/c * C57BL/6 * INT

 MP:0000664 small coagulating gland "reduced size of the coagulating gland" [J:64981]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001158 abnormal prostate morphology "mallformed gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Fkbp4tm1Dvds/Fkbp4tm1Dvds
Genetic Background: either: (involves: CD-1) or (involves: 129X1/SvJ * C57BL/6)

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0002212 abnormal secondary sex determination "gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Fkbp4tm1Dvds/Fkbp4tm1Dvds
Genetic Background: either: (involves: CD-1) or (involves: 129X1/SvJ * C57BL/6)

 MP:0002771 absent coagulating gland "missing anterior lobe of the prostate" [J:78062, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0002789 male pseudohermaphroditism "pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0003124 hypospadia "a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou,Fkbp5Gt(RRC236)Byg/Fkbp5+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003553 abnormal foreskin morphology "anomaly of the loose fold of skin that covers the penis" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0005187 abnormal penis morphology "anomalous structure of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0005188 small penis "in comparison to the norm, reduced size of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0005189 abnormal anogenital distance "in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp4tm1Dvds/Fkbp4tm1Dvds
Genetic Background: either: (involves: CD-1) or (involves: 129X1/SvJ * C57BL/6)

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J)

 MP:0009735 abnormal prostate gland development "anomaly in the formation or pattering of the of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Fkbp4tm1Shou/Fkbp4tm1Shou
Genetic Background: involves: 129S/SvEv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction / complex
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / complex / reaction
 ENSMUSG00000024222 Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*  / reaction
 ENSMUSG00000031870 Pgr / Q00175 / Progesterone receptor / P06401*  / complex
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction / complex
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / reaction / complex
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / complex / reaction
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / reaction / complex






 

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