ENSMUSG00000032966


Mus musculus

Features
Gene ID: ENSMUSG00000032966
  
Biological name :Fkbp1a
  
Synonyms : Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A
  
Possible biological names infered from orthology : FK506 binding protein 1A / FK506 binding protein 1C / FKBP1C / P62942
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: G3
Gene start: 151542483
Gene end: 151561692
  
Corresponding Affymetrix probe sets: 10477012 (MoGene1.0st)   1416036_at (Mouse Genome 430 2.0 Array)   1438958_x_at (Mouse Genome 430 2.0 Array)   1448184_at (Mouse Genome 430 2.0 Array)   1456196_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118725
Ensembl peptide - ENSMUSP00000037206
NCBI entrez gene - 14225     See in Manteia.
MGI - MGI:95541
RefSeq - NM_001302080
RefSeq - NM_008019
RefSeq - XM_017315525
RefSeq - NM_001302077
RefSeq - NM_001302078
RefSeq - NM_001302079
RefSeq - XM_011239292
RefSeq Peptide - NP_032045
RefSeq Peptide - NP_001289008
RefSeq Peptide - NP_001289009
RefSeq Peptide - NP_001289007
RefSeq Peptide - NP_001289006
swissprot - F6X9I3
swissprot - P26883
Ensembl - ENSMUSG00000032966
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FKBP1CENSGALG00000027151Gallus gallus
 FKBP1AENSG00000088832Homo sapiens
 FKBP1CENSG00000198225Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fkbp1b / Q9Z2I2 / Peptidyl-prolyl cis-trans isomerase FKBP1B / P68106* / FK506 binding protein 1B*ENSMUSG0000002063581
Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*ENSMUSG0000003035751
Fkbp3 / Q62446 / Peptidyl-prolyl cis-trans isomerase FKBP3 / Q00688* / FK506 binding protein 3*ENSMUSG0000002094947
Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*ENSMUSG0000002422247


Protein motifs (from Interpro)
Interpro ID Name
 IPR001179  FKBP-type peptidyl-prolyl cis-trans isomerase domain
 IPR023566  Peptidyl-prolyl cis-trans isomerase, FKBP-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization ISO
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006936 muscle contraction IMP
 biological_processGO:0007183 SMAD protein complex assembly ISO
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IMP
 biological_processGO:0031000 response to caffeine IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0032880 regulation of protein localization ISO
 biological_processGO:0032925 regulation of activin receptor signaling pathway ISO
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0050776 regulation of immune response ISO
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IMP
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0097435 supramolecular fiber organization ISO
 biological_processGO:1902991 regulation of amyloid precursor protein catabolic process ISO
 biological_processGO:1990000 amyloid fibril formation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0030018 Z disc ISO
 cellular_componentGO:0031312 extrinsic component of organelle membrane ISS
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0098562 cytoplasmic side of membrane ISS
 cellular_componentGO:1990425 ryanodine receptor complex ISS
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005528 FK506 binding IEA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0048185 activin binding ISO


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling activates SMADs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: LdlrHlb301/Ldlr+
Genetic Background: C57BL/6J-LdlrHlb301/J

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pi4katm2.1Arte/Pi4ka+,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6NTac

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004032 abnormal interventricular groove "malformation of the intendation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mgat1tm2Jxm/Mgat1tm1Pst,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: Odf1tm1Shf/Odf1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010556 thin ventricle myocardium compact layer "reduced thickness of the ventricular portion of the outer, dense layer of the myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fkbp1atm1.1Shou/Fkbp1atm1Zuk,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fkbp1atm1Zuk/Fkbp1atm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Fkbp1atm1Slh/Fkbp1atm1Slh,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002603 Tgfb1 / P04202 / transforming growth factor, beta 1 / P01137*  / reaction
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction
 ENSMUSG00000007613 Q64729 / Tgfbr1 / transforming growth factor, beta receptor I / P36897* / transforming growth factor beta receptor 1*  / reaction / complex
 ENSMUSG00000032966 Fkbp1a / P26883 / Peptidyl-prolyl cis-trans isomerase FKBP1A / FKBP1C* / P62942* / FK506 binding protein 1C* / FK506 binding protein 1A*  / reaction






 

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