ENSGALG00000006512


Gallus gallus

Features
Gene ID: ENSGALG00000006512
  
Biological name :HSPA8
  
Synonyms : heat shock cognate 71 kDa protein / HSPA8
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 8 / P11142 / P63017
  
Species: Gallus gallus
  
Chr. number: 24
Strand: 1
Band:
Gene start: 3073404
Gene end: 3080079
  
Corresponding Affymetrix probe sets: Gga.4555.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000058055
Ensembl peptide - ENSGALP00000061065
Ensembl peptide - ENSGALP00000060675
Ensembl peptide - ENSGALP00000060588
Ensembl peptide - ENSGALP00000059068
Ensembl peptide - ENSGALP00000010510
Ensembl peptide - ENSGALP00000051563
NCBI entrez gene - 395853     See in Manteia.
RefSeq - NM_205003
RefSeq Peptide - NP_990334
swissprot - A0A1D5PYK0
swissprot - A0A1L1RPG0
swissprot - F1NWP3
swissprot - A0A1D5PFJ6
swissprot - A0A1L1RJY5
Ensembl - ENSGALG00000006512
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa8ENSDARG00000068992Danio rerio
 si:dkey-4p15.3ENSDARG00000037403Danio rerio
 HSPA8ENSG00000109971Homo sapiens
 Hspa8ENSMUSG00000015656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA2 / heat shock 70 kDa protein / P17156* / P54652* / Heat shock-related 70 kDa protein 2 * / heat shock protein family A (Hsp70) member 2*ENSGALG0000001171587
HSPA5 / Q90593 / 78 kDa glucose-regulated protein / P11021* / P20029* / heat shock protein 5* / heat shock protein family A (Hsp70) member 5*ENSGALG0000000100064
HSPA5* / P11021* / P20029* / heat shock protein 5* / heat shock protein family A (Hsp70) member 5*ENSGALG0000003349839
HSPA14* / Q0VDF9* / Q99M31* / Heat shock 70 kDa protein 14 * / heat shock protein family A (Hsp70) member 14*ENSGALG0000003520122


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0007369 gastrulation IEP
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEP
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0042026 protein refolding IEA
 biological_processGO:0044788 modulation by host of viral process IEA
 biological_processGO:0044829 positive regulation by host of viral genome replication IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0046034 ATP metabolic process IEA
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
 biological_processGO:0048568 embryonic organ development IEP
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0061738 late endosomal microautophagy IEA
 biological_processGO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy IEA
 biological_processGO:0072318 clathrin coat disassembly IEA
 biological_processGO:1902904 negative regulation of supramolecular fiber organization IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000974 Prp19 complex IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042623 ATPase activity, coupled IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IPI
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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