ENSMUSG00000059970


Mus musculus

Features
Gene ID: ENSMUSG00000059970
  
Biological name :Hspa2
  
Synonyms : Heat shock-related 70 kDa protein 2 / Hspa2 / P17156
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 2 / P54652
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 76404176
Gene end: 76406938
  
Corresponding Affymetrix probe sets: 10396652 (MoGene1.0st)   1417101_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079306
Ensembl peptide - ENSMUSP00000151408
NCBI entrez gene - 15512     See in Manteia.
MGI - MGI:96243
RefSeq - XM_006515484
RefSeq - NM_001002012
RefSeq - NM_008301
RefSeq Peptide - NP_032327
RefSeq Peptide - NP_001002012
swissprot - P17156
Ensembl - ENSMUSG00000059970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSPA2ENSGALG00000011715Gallus gallus
 HSPA2ENSG00000126803Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*ENSMUSG0000001565687
P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG0000009087784
Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG0000009197184
Hspa1l / P16627 / Heat shock 70 kDa protein 1-like / P34931* / heat shock protein family A (Hsp70) member 1 like*ENSMUSG0000000703383
Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*ENSMUSG0000002686463
Hspa14 / Q99M31 / Heat shock 70 kDa protein 14 / Q0VDF9* / heat shock protein family A (Hsp70) member 14*ENSMUSG0000010986527


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0009408 response to heat ISS
 biological_processGO:0009409 response to cold ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032781 positive regulation of ATPase activity IMP
 biological_processGO:0042026 protein refolding IEA
 biological_processGO:0070194 synaptonemal complex disassembly IMP
 biological_processGO:0090084 negative regulation of inclusion body assembly IEA
 biological_processGO:1901896 positive regulation of calcium-transporting ATPase activity IMP
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0036128 CatSper complex IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0072687 meiotic spindle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051861 glycolipid binding IDA
 molecular_functionGO:0097718 disordered domain specific binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rxratm1Krc/Rxratm1Krc,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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