ENSMUSG00000032030


Mus musculus

Features
Gene ID: ENSMUSG00000032030
  
Biological name :Cul5
  
Synonyms : Cul5 / cullin 5
  
Possible biological names infered from orthology : Q93034
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 53614582
Gene end: 53670014
  
Corresponding Affymetrix probe sets: 10593605 (MoGene1.0st)   1428287_at (Mouse Genome 430 2.0 Array)   1452722_a_at (Mouse Genome 430 2.0 Array)   1456102_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133144
Ensembl peptide - ENSMUSP00000034529
Ensembl peptide - ENSMUSP00000113490
Ensembl peptide - ENSMUSP00000121734
NCBI entrez gene - 75717     See in Manteia.
MGI - MGI:1922967
RefSeq - XM_017313680
RefSeq - NM_001161618
RefSeq - NM_027807
RefSeq Peptide - NP_082083
RefSeq Peptide - NP_001155090
swissprot - E9Q6Z0
swissprot - E9PV12
swissprot - F8VQI6
swissprot - G3X914
Ensembl - ENSMUSG00000032030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul5aENSDARG00000069742Danio rerio
 cul5bENSDARG00000004260Danio rerio
 CUL5ENSGALG00000017165Gallus gallus
 CUL5ENSG00000166266Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*ENSMUSG0000002968626
Cul4b / A2A432 / Cullin-4B / Q13620*ENSMUSG0000003109525
Cul2 / Q9D4H8 / Cullin-2 / Q13617*ENSMUSG0000002423124
Cul4a / Q3TCH7 / Cullin-4A / Q13619*ENSMUSG0000003144624
Cul3 / Q9JLV5 / Cullin-3 / Q13618*ENSMUSG0000000436421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mir137tm1.2Mtm/Mir137tm1.2Mtm
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mir137tm1.2Mtm/Mir137tm1.2Mtm
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J

 MP:0008655 decreased interleukin-1 alpha secretion "reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
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Allelic Composition: Mir137tm1.2Mtm/Mir137tm1.2Mtm
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Mir137tm1.2Mtm/Mir137tm1.2Mtm
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mir137tm1.2Mtm/Mir137tm1.2Mtm
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079658 Eloc / P83940 / Elongin-C / Q15369*  / complex
 ENSMUSG00000028703 Lrrc41 / Q8K1C9 / Leucine-rich repeat-containing protein 41 / Q15345* / leucine rich repeat containing 41*  / complex
 ENSMUSG00000038037 Socs1 / O35716 / Suppressor of cytokine signaling 1 / O15524*  / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / complex
 ENSMUSG00000055839 Elob / P62869 / Elongin-B / Q15370*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex






 

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