ENSG00000166266


Homo sapiens

Features
Gene ID: ENSG00000166266
  
Biological name :CUL5
  
Synonyms : CUL5 / cullin 5 / Q93034
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q22.3
Gene start: 108008733
Gene end: 108107776
  
Corresponding Affymetrix probe sets: 203531_at (Human Genome U133 Plus 2.0 Array)   203532_x_at (Human Genome U133 Plus 2.0 Array)   203533_s_at (Human Genome U133 Plus 2.0 Array)   230393_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436494
Ensembl peptide - ENSP00000376808
Ensembl peptide - ENSP00000431221
Ensembl peptide - ENSP00000435376
NCBI entrez gene - 8065     See in Manteia.
OMIM - 601741
RefSeq - XM_017018365
RefSeq - NM_003478
RefSeq - XM_005271682
RefSeq - XM_017018363
RefSeq - XM_017018364
RefSeq Peptide - NP_003469
swissprot - H0YCA0
swissprot - E9PP19
swissprot - Q93034
Ensembl - ENSG00000166266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul5aENSDARG00000069742Danio rerio
 cul5bENSDARG00000004260Danio rerio
 CUL5ENSGALG00000017165Gallus gallus
 Cul5ENSMUSG00000032030Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL1 / Q13616 / cullin 1ENSG0000005513029
CUL2 / Q13617 / cullin 2ENSG0000010809426
CUL4A / Q13619 / cullin 4AENSG0000013984226
CUL4B / Q13620 / cullin 4BENSG0000015829026
CUL3 / Q13618 / cullin 3ENSG0000003625724


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IDA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Vif-mediated degradation of APOBEC3G
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex
 ENSG00000132128 LRRC41 / Q15345 / leucine rich repeat containing 41  / complex
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex
 ENSG00000239713 Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3G  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr