ENSG00000239713


Homo sapiens

Features
Gene ID: ENSG00000239713
  
Biological name :APOBEC3G
  
Synonyms : APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3G / Q9HC16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 39077005
Gene end: 39087743
  
Corresponding Affymetrix probe sets: 204205_at (Human Genome U133 Plus 2.0 Array)   214995_s_at (Human Genome U133 Plus 2.0 Array)   215579_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385057
NCBI entrez gene - 60489     See in Manteia.
OMIM - 607113
RefSeq - XM_017028904
RefSeq - NM_021822
RefSeq - XM_006724290
RefSeq - XM_017028903
RefSeq Peptide - NP_068594
swissprot - Q9HC16
Ensembl - ENSG00000239713
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UH17 / APOBEC3B / apolipoprotein B mRNA editing enzyme catalytic subunit 3BENSG0000017975056
Q8IUX4 / APOBEC3F / apolipoprotein B mRNA editing enzyme catalytic subunit 3FENSG0000012839450
AL022318.4ENSG0000028455442
Q96AK3 / APOBEC3D / apolipoprotein B mRNA editing enzyme catalytic subunit 3DENSG0000024381142
P31941 / APOBEC3A / apolipoprotein B mRNA editing enzyme catalytic subunit 3AENSG0000012838334
Q9NRW3 / APOBEC3C / apolipoprotein B mRNA editing enzyme catalytic subunit 3CENSG0000024450921
AICDA / Q9GZX7 / activation induced cytidine deaminaseENSG0000011173221
Q9Y235 / APOBEC2 / apolipoprotein B mRNA editing enzyme catalytic subunit 2ENSG0000012470117
Q6NTF7 / APOBEC3H / apolipoprotein B mRNA editing enzyme catalytic subunit 3HENSG0000010029817
P41238 / APOBEC1 / apolipoprotein B mRNA editing enzyme catalytic subunit 1ENSG0000011170114


Protein motifs (from Interpro)
Interpro ID Name
 IPR002125  Cytidine and deoxycytidylate deaminase domain
 IPR013158  APOBEC-like, N-terminal
 IPR016192  APOBEC/CMP deaminase, zinc-binding
 IPR016193  Cytidine deaminase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009972 cytidine deamination IDA
 biological_processGO:0010529 negative regulation of transposition IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016553 base conversion or substitution editing TAS
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
 biological_processGO:0048525 negative regulation of viral process IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0070383 DNA cytosine deamination IDA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030895 apolipoprotein B mRNA editing enzyme complex TAS
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004126 cytidine deaminase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0008829 dCTP deaminase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity NAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047844 deoxycytidine deaminase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000239713 Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3G  / reaction
 ENSG00000103363 ELOB / Q15370 / elongin B  / reaction / complex
 ENSG00000166266 CUL5 / Q93034 / cullin 5  / reaction / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000154582 ELOC / Q15369 / elongin C  / reaction / complex






 

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