ENSG00000111701


Homo sapiens

Features
Gene ID: ENSG00000111701
  
Biological name :APOBEC1
  
Synonyms : APOBEC1 / apolipoprotein B mRNA editing enzyme catalytic subunit 1 / P41238
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 7649400
Gene end: 7665903
  
Corresponding Affymetrix probe sets: 207158_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436415
Ensembl peptide - ENSP00000229304
NCBI entrez gene - 339     See in Manteia.
OMIM - 600130
RefSeq - NM_001644
RefSeq - NM_001304566
RefSeq - NM_005889
RefSeq Peptide - NP_001291495
RefSeq Peptide - NP_001635
RefSeq Peptide - NP_005880
swissprot - P41238
swissprot - A0A0B4J232
Ensembl - ENSG00000111701
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P51908ENSMUSG00000040613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IUX4 / APOBEC3F / apolipoprotein B mRNA editing enzyme catalytic subunit 3FENSG0000012839425
AICDA / Q9GZX7 / activation induced cytidine deaminaseENSG0000011173224
AL022318.4ENSG0000028455424
Q96AK3 / APOBEC3D / apolipoprotein B mRNA editing enzyme catalytic subunit 3DENSG0000024381124
Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3GENSG0000023971323
Q9NRW3 / APOBEC3C / apolipoprotein B mRNA editing enzyme catalytic subunit 3CENSG0000024450922
Q9UH17 / APOBEC3B / apolipoprotein B mRNA editing enzyme catalytic subunit 3BENSG0000017975022
P31941 / APOBEC3A / apolipoprotein B mRNA editing enzyme catalytic subunit 3AENSG0000012838322
Q6NTF7 / APOBEC3H / apolipoprotein B mRNA editing enzyme catalytic subunit 3HENSG0000010029819
Q9Y235 / APOBEC2 / apolipoprotein B mRNA editing enzyme catalytic subunit 2ENSG0000012470118


Protein motifs (from Interpro)
Interpro ID Name
 IPR002125  Cytidine and deoxycytidylate deaminase domain
 IPR013158  APOBEC-like, N-terminal
 IPR016192  APOBEC/CMP deaminase, zinc-binding
 IPR016193  Cytidine deaminase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0009972 cytidine deamination IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0016554 cytidine to uridine editing TAS
 biological_processGO:0016556 mRNA modification IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042157 lipoprotein metabolic process IEA
 biological_processGO:0042158 lipoprotein biosynthetic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042953 lipoprotein transport IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048255 mRNA stabilization IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0070383 DNA cytosine deamination IEA
 biological_processGO:0080111 DNA demethylation IEA
 biological_processGO:0090209 negative regulation of triglyceride metabolic process IEA
 biological_processGO:0090310 negative regulation of methylation-dependent chromatin silencing IEA
 biological_processGO:0090366 positive regulation of mRNA modification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004126 cytidine deaminase activity IEA
 molecular_functionGO:0004131 cytosine deaminase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
 molecular_functionGO:0017091 AU-rich element binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
mRNA Editing: C to U Conversion
Formation of the Editosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148584 A1CF / Q9NQ94 / APOBEC1 complementation factor  / reaction / complex
 ENSG00000111701 P41238 / APOBEC1 / apolipoprotein B mRNA editing enzyme catalytic subunit 1  / reaction






 

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