ENSMUSG00000040613


Mus musculus

Features
Gene ID: ENSMUSG00000040613
  
Biological name :Apobec1
  
Synonyms : Apobec1 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 / P51908
  
Possible biological names infered from orthology : apolipoprotein B mRNA editing enzyme catalytic subunit 1 / P41238
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F1
Gene start: 122577792
Gene end: 122602444
  
Corresponding Affymetrix probe sets: 10547621 (MoGene1.0st)   1451755_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108206
Ensembl peptide - ENSMUSP00000145417
Ensembl peptide - ENSMUSP00000145154
Ensembl peptide - ENSMUSP00000144996
Ensembl peptide - ENSMUSP00000116238
Ensembl peptide - ENSMUSP00000108204
Ensembl peptide - ENSMUSP00000108205
NCBI entrez gene - 11810     See in Manteia.
MGI - MGI:103298
RefSeq - XM_011241159
RefSeq - NM_001134391
RefSeq - NM_031159
RefSeq - XM_006505401
RefSeq Peptide - NP_001127863
RefSeq Peptide - NP_112436
swissprot - P51908
swissprot - A0A0N4SVL6
swissprot - A0A0N4SV86
swissprot - Q3U9G8
swissprot - A0A0N4SW85
swissprot - D3Z675
Ensembl - ENSMUSG00000040613
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P41238ENSG00000111701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aicda / Q9WVE0 / Single-stranded DNA cytosine deaminase / Q9GZX7* / activation induced cytidine deaminase*ENSMUSG0000004062725
Q99J72 / Apobec3 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 / Q6NTF7* / APOBEC3H* / apolipoprotein B mRNA editing enzyme catalytic subunit 3H*ENSMUSG0000000958522
Q9WV35 / Apobec2 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 / Q9Y235* / apolipoprotein B mRNA editing enzyme catalytic subunit 2*ENSMUSG0000004069418


Protein motifs (from Interpro)
Interpro ID Name
 IPR002125  Cytidine and deoxycytidylate deaminase domain
 IPR013158  APOBEC-like, N-terminal
 IPR016192  APOBEC/CMP deaminase, zinc-binding
 IPR016193  Cytidine deaminase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006641 triglyceride metabolic process IGI
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0009972 cytidine deamination IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010332 response to gamma radiation IMP
 biological_processGO:0016554 cytidine to uridine editing IMP
 biological_processGO:0016556 mRNA modification IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0042157 lipoprotein metabolic process IMP
 biological_processGO:0042158 lipoprotein biosynthetic process IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042953 lipoprotein transport IGI
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048255 mRNA stabilization IDA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0070383 DNA cytosine deamination IEA
 biological_processGO:0080111 DNA demethylation IDA
 biological_processGO:0090209 negative regulation of triglyceride metabolic process IGI
 biological_processGO:0090310 negative regulation of methylation-dependent chromatin silencing IMP
 biological_processGO:0090366 positive regulation of mRNA modification IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004126 cytidine deaminase activity ISO
 molecular_functionGO:0004131 cytosine deaminase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
 molecular_functionGO:0017091 AU-rich element binding IDA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
mRNA Editing: C to U Conversion
Formation of the Editosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il13tm2Anjm/Il13tm2Anjm
Genetic Background: involves: 129

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Apobec1tm1Ddsn Ldlrtm1Her

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Tg(CETP)5203Tall/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Apobec1tm1Ishi/Apobec1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Tg(CETP)5203Tall/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub
Genetic Background: involves: C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Tg(CETP)5203Tall/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxm1tm1Rhc/Foxm1tm1Rhc,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Apobec1tm1Ishi/Apobec1tm1Ishi,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Tg(CETP)5203Tall/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobec1tm1Rub/Apobec1tm1Rub,Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apobec1tm1Chan/Apobec1tm1Chan,Apoetm1Unc/Apoetm1Unc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Apobec1tm1Ddsn Ldlrtm1Her

Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Fggtm1Fjc/Fggtm1Fjc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Fggtm1Fjc Apobec1tm1Ddsn Ldlrtm1Her

 MP:0012223 increased prothrombin level "greater level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade" [MGI:csmith]
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Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Apobec1tm1Ddsn Ldlrtm1Her

 MP:0012326 increased circulating antithrombin level "higher than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation" [ISBN:0-683-40008-8, MPD:Molly]
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Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Apobec1tm1Ddsn Ldlrtm1Her

 MP:0012355 decreased prothrombin time "decreased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]
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Allelic Composition: Apobec1tm1Ddsn/Apobec1tm1Ddsn,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Apobec1tm1Ddsn Ldlrtm1Her

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052595 A1cf / Q5YD48 / APOBEC1 complementation factor / Q9NQ94*  / reaction / complex
 ENSMUSG00000040613 P51908 / Apobec1 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 / P41238* / apolipoprotein B mRNA editing enzyme catalytic subunit 1*  / reaction






 

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