| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0000277 | abnormal heart shape | "malformation of the form or the patterning of the heart" [J:18048] |
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0000343 | altered response to myocardial infarction | "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Tnni3ktm1Tfo/Tnni3ktm1Tfo,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
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Allelic Composition: Chl1tm1Mtg/Chl1tm1Mtg
Genetic Background: B6.129P2-Chl1tm1Mtg
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Emdtm1.1Stw/Y
Genetic Background: involves: 129S1/Sv * C57BL/6
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| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0001853 | heart inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0001855 | atrial thrombosis | "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0002078 | abnormal glucose homeostasis | "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Cacna1ctm1Ggm/Cacna1ctm1Ggm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N
Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Ryr2tm1Krbr/Ryr2tm3.1Swch,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
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| MP:0002127 | abnormal cardiovascular system morphology | "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ltatm1Dch/Ltatm1Dch
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zdhhc13Gt(AC0492)Wtsi/Zdhhc13Gt(AC0492)Wtsi
Genetic Background: FVB.129P2-Zdhhc13Gt(AC0492)Wtsi
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| MP:0002190 | disorganized myocardium | "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044] |
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0002625 | left ventricle hypertrophy | "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0002626 | increased heart rate | "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0002754 | dilated right ventricle | "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
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| MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Ctnna1tm1Efu/Ctnna1tm1Efu,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129X1/SvJ * FVB/N
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N
Allelic Composition: A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N
Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Pik3catm1.1Rzl/Pik3catm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
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| MP:0002953 | thick ventricular wall | "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Pik3catm1.1Rzl/Pik3catm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N
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| MP:0003038 | decreased infarction size | "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Gdf9-icre)5092Coo/0
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Tnni3ktm1Tfo/Tnni3ktm1Tfo,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0003061 | decreased aerobic running capacity | "reduced ability to run at defined speeds and/or distances compared to controls" [RGD:Rat Genome Database submission] |
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Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
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| MP:0003137 | abnormal impulse conducting system conduction | "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
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| MP:0003140 | dilated atria | "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0003222 | increased cardiomyocyte apoptosis | "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0003223 | decreased cardiomyocyte apoptosis | "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0003393 | decreased cardiac output | "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0003822 | decreased left ventricle systolic pressure | "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission] |
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0003828 | pulmonary edema | "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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| MP:0003896 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0003915 | increased left ventricle weight | "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
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| MP:0003923 | abnormal left atrium morphology | "structural anomaly of the left upper chamber of the heart " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0003928 | increased heart rate variability | "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004011 | decreased diastolic filling velocity | "reduction in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders" [RGD:Rat Genome Database submission] |
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Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0004084 | abnormal cardiac muscle relaxation | "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0004090 | abnormal sarcomere morphology | "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0004091 | abnormal Z lines | "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0004093 | diffuse Z lines | "widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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| MP:0004114 | abnormal atrioventricular node morphology | "structural anomaly in the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004121 | abnormal sarcolemma morphology | "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0004122 | sinus arrhythmia | "irregular heartbeat related to abnormal function of the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004145 | abnormal muscle electrophysiology | "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cacna1ctm3Hfm/Cacna1ctm4Hfm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N
Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Pik3catm1.1Rzl/Pik3catm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Tnni3ktm1Tfo/Tnni3ktm1Tfo,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N
Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004484 | altered response of heart to induced stress | "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Txniptm1.1Rlee/Txniptm1.1Rlee
Genetic Background: involves: 129S4/SvJae
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| MP:0004485 | increased response of heart to induced stress | "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004486 | decreased response of heart to induced stress | "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om
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| MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N
Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Wdr1tm1.1Zzy/Wdr1tm1.1Zzy,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0004565 | small myocardial fiber | "decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Pik3catm1.1Rzl/Pik3catm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Cacna1ctm1Ggm/Cacna1ctm1Ggm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N
Allelic Composition: A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N
Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cfTg(Myh6-cre/Esr1*)1Jmk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
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| MP:0005166 | decreased susceptiblity to injury | "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know
Genetic Background: involves: C3H
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| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0005282 | decreased fatty acid level | "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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| MP:0005290 | decreased oxygen consumption | "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0005318 | decreased triglyceride level | "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
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| MP:0005324 | ascites | "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0005330 | cardiomyopathy | "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681] |
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Ryr2tm1Krbr/Ryr2tm3.1Swch,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005406 | abnormal heart size | "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N
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| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Mcutm1.1Jmol/Mcutm1.1Jmol,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0005599 | increased cardiac muscle contractility | "greater than the normal ability of the heart muscle to shorten or to develop increased tension
" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N
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| MP:0005602 | decreased angiogenesis | "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hif1atm1Stom/Hif1atm1Stom,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB/N
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| MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0005630 | increased lung weight | "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission] |
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N
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| MP:0005665 | increased circulating noradrenaline level | "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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| MP:0006141 | abnormal atrioventricular node conduction | "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ptgs1tm1Unc/Ptgs1+,Ptgs2tm1Unc/Ptgs2tm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0006142 | abnormal sinoatrial node conduction | "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
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| MP:0006264 | decreased systolic blood pressure | "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0006267 | abnormal intercalated disc morphology | "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280] |
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Allelic Composition: Cdh2tm1Glr/Cdh2Gt(OST49160)Lex,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Cdh2tm1Glr/Cdh2tm1Hyn,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N
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| MP:0006321 | increased myocardial fiber number | "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129 * C57BL/6 * FVB/N
Allelic Composition: A1cfTg(Myh6-cre/Esr1*)1Jmk/?,Tnni3ktm1Tfo/Tnni3ktm1Tfo
Genetic Background: involves: C57BL/6 * FVB/N
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| MP:0008022 | dilated heart ventricles | "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cacna1ctm1Ggm/Cacna1ctm1Ggm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Eif4ebp1tm1Nso/Eif4ebp1tm1Nso,Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
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| MP:0008725 | enlarged heart atrium | "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0008751 | abnormal interleukin level | "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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| MP:0008772 | enlarged heart ventricle | "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0008950 | ventricular tachycardia | "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
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| MP:0010334 | pleural effusion | "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
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| MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Irx3tm3Hui/Irx3tm3Hui,Irx5tm3Hui/Irx5tm3Hui,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0010505 | abnormal T wave | "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0010519 | atrioventricular block | "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0010563 | increased heart right ventricle size | "greater than average size of the right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
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| MP:0010579 | increased heart left ventricle size | "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pik3catm1.1Rzl/Pik3catm1.1Rzl,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Juptm1.1Glr/Juptm1.1Glr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
Allelic Composition: Srftm1Zli/Srftm1Zli,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129 * C57BL/6J * FVB/N
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| MP:0010637 | sinus bradycardia | "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ryr2tm1Krbr/Ryr2tm1Krbr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0010725 | thin interventricular septum | "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0010754 | abnormal heart left ventricle pressure | "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
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| MP:0010955 | abnormal respiratory electron transport chain | "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0010959 | abnormal oxidative phosphorylation | "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
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| MP:0011094 | complete embryonic lethality before implantation | "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith] |
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Allelic Composition: Tnftm3Gkl/Tnftm3Gkl
Genetic Background: involves: 129S/SvEv * C57BL/6
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| MP:0011632 | dilated mitochondria | "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0011633 | abnormal mitochondrial shape | "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011634 | abnormal mitochondrial inner membrane morphology | "any structural anomaly of the inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope, which is highly folded to form cristae" [GO:0005743] |
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0011915 | increased heart left atrium weight | "more than average weight of the left atrium" [MPD:Molly] |
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Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0011925 | abnormal heart echocardiography feature | "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly] |
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N
Allelic Composition: Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: BALB/c * C57BL/6 * FVB/N
Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
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| MP:0011953 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly] |
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Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N
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| MP:0012106 | impaired exercise endurance | "impaired performance during controlled physical activity" [MGI:smb] |
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Allelic Composition: Ptgs2tm1Gaf/Ptgs2tm1Gaf,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N
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| MP:0012688 | abnormal heart ventricles weight | "abnormal average weight of both the left and right ventricles together" [MPD:Molly] |
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Allelic Composition: Akap6tm1.1Mskf/Akap6tm1.1Mskf,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: C57BL/6 * FVB/N * SJL
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| MP:0013272 | abnormal translation | "any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412] |
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Allelic Composition: Mtortm1.1Gcon/Mtortm1.1Gcon,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0014172 | decreased fatty acid oxidation | |
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Allelic Composition: Cd36tm2.1Mfe/Cd36tm2.1Mfe,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk
Allelic Composition: Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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| MP:0020367 | increased heart iron level | "increase in the amount of iron present in the heart tissue" [MGI:Anna] |
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB
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| MP:0030018 | increased cardiac cell glucose uptake | "increased ability of the cells of the heart to take in glucose" [MGI:anna] |
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Allelic Composition: Txniptm1Rlee/Txniptm1Rlee,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S4/SvJae * FVB/N
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