ENSMUSG00000044595


Mus musculus

Features
Gene ID: ENSMUSG00000044595
  
Biological name :Dnd1
  
Synonyms : Dead end protein homolog 1 / Dnd1 / Q6VY05
  
Possible biological names infered from orthology : DND microRNA-mediated repression inhibitor 1 / Q8IYX4
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 36763671
Gene end: 36766214
  
Corresponding Affymetrix probe sets: 10458391 (MoGene1.0st)   1455367_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054412
NCBI entrez gene - 213236     See in Manteia.
MGI - MGI:2447763
RefSeq - NM_173383
RefSeq Peptide - NP_775559
swissprot - Q6VY05
Ensembl - ENSMUSG00000044595
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnd1ENSDARG00000022813Danio rerio
 DND1ENSG00000256453Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A1cf / Q5YD48 / APOBEC1 complementation factor / Q9NQ94*ENSMUSG0000005259534
Rbm46 / P86049 / Probable RNA-binding protein 46 / Q8TBY0* / RNA binding motif protein 46*ENSMUSG0000003388231
Rbm47 / Q91WT8 / RNA-binding protein 47 / A0AV96* / RNA binding motif protein 47*ENSMUSG0000007078029
Hnrnpr / heteroous nuclear ribonucleoprotein R isoform a / O43390* / heterogeneous nuclear ribonucleoprotein R*ENSMUSG0000006603723
Q7TMK9 / Syncrip / synaptotagmin binding, cytoplasmic RNA interacting protein / O60506*ENSMUSG0000003242322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034414  Dead end protein 1, RNA recognition motif 1
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0060965 negative regulation of gene silencing by miRNA IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017091 AU-rich element binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: B6.129P2-Plgtm1Jld

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: B6.129P2-Plgtm1Jld

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: B6.129P2-Plgtm1Jld

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnd1Ter/Dnd1Ter,Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: B6.129P2-Plgtm1Jld

Allelic Composition: Dnd1Ter/Dnd1Ter,Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trpv3tm1.2Clph/Trpv3tm1.2Clph
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * CBA

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J

 MP:0004478 testicular teratoma "neoplasms found in the testis that are composed of multiple tissue types; includes types not normally found in tesis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: B6.129P2-Plgtm1Jld

Allelic Composition: Dnd1Ter/Dnd1Ter
Genetic Background: 129S1/Sv-KitW Oca2p Tyrc-ch

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: 129S1/Sv-KitW Oca2p Tyrc-ch

Allelic Composition: Dnd1Ter/Dnd1Ter
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter
Genetic Background: 129S1/Sv-KitW Oca2p Tyrc-ch

Allelic Composition: Dnd1tm1Na/Dnd1Ter
Genetic Background: involves: 129P3/J * 129S6/SvEvTac

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter
Genetic Background: 129S1/Sv-KitW Oca2p Tyrc-ch

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnd1Ter/Dnd1Ter
Genetic Background: 129S1/Sv-KitW Oca2p Tyrc-ch

Allelic Composition: Dnd1tm1Na/Dnd1Ter
Genetic Background: involves: 129P3/J * 129S6/SvEvTac

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: B6.129P2-Plgtm1Jld

 MP:0006262 testis tumor "presence of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:60034]
Show

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Dnd1Ter/Dnd1Ter,Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * 129T1/Sv

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129P3/J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5bp-6J/Gdf5bp-6J
Genetic Background: DBA/2J-Gdf5bp-6J/GrsrJ

Allelic Composition: Dnd1tm1Na/Dnd1Ter
Genetic Background: involves: 129P3/J * 129S6/SvEvTac

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Gdf5bp-6J/Gdf5bp-6J
Genetic Background: DBA/2J-Gdf5bp-6J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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