ENSMUSG00000040694


Mus musculus

Features
Gene ID: ENSMUSG00000040694
  
Biological name :Apobec2
  
Synonyms : Apobec2 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 / Q9WV35
  
Possible biological names infered from orthology : apolipoprotein B mRNA editing enzyme catalytic subunit 2 / Q9Y235
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 48419231
Gene end: 48432728
  
Corresponding Affymetrix probe sets: 10451665 (MoGene1.0st)   1417889_at (Mouse Genome 430 2.0 Array)   1444348_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047402
NCBI entrez gene - 11811     See in Manteia.
MGI - MGI:1343178
RefSeq - NM_009694
RefSeq Peptide - NP_033824
swissprot - Q9WV35
Ensembl - ENSMUSG00000040694
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apobec2aENSDARG00000018881Danio rerio
 apobec2bENSDARG00000113992Danio rerio
 APOBEC2ENSGALG00000003226Gallus gallus
 Q9Y235ENSG00000124701Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aicda / Q9WVE0 / Single-stranded DNA cytosine deaminase / Q9GZX7* / activation induced cytidine deaminase*ENSMUSG0000004062726
Q99J72 / Apobec3 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 / Q6NTF7* / APOBEC3H* / apolipoprotein B mRNA editing enzyme catalytic subunit 3H*ENSMUSG0000000958524
P51908 / Apobec1 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 / P41238* / apolipoprotein B mRNA editing enzyme catalytic subunit 1*ENSMUSG0000004061318


Protein motifs (from Interpro)
Interpro ID Name
 IPR002125  Cytidine and deoxycytidylate deaminase domain
 IPR013158  APOBEC-like, N-terminal
 IPR016193  Cytidine deaminase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0009972 cytidine deamination IEA
 biological_processGO:0016554 cytidine to uridine editing IEA
 biological_processGO:0016556 mRNA modification IMP
 biological_processGO:0080111 DNA demethylation IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004126 cytidine deaminase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
mRNA Editing: C to U Conversion
Formation of the Editosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003081 abnormal soleus morphology "anomaly in the the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0009426 decreased soleus weight "reduction in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0009428 decreased tibialis anterior weight "redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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