ENSMUSG00000009585


Mus musculus

Features
Gene ID: ENSMUSG00000009585
  
Biological name :Apobec3
  
Synonyms : Apobec3 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 / Q99J72
  
Possible biological names infered from orthology : APOBEC3H / apolipoprotein B mRNA editing enzyme catalytic subunit 3H / Q6NTF7
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 79891659
Gene end: 79915906
  
Corresponding Affymetrix probe sets: 10425321 (MoGene1.0st)   10425333 (MoGene1.0st)   1417470_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155852
Ensembl peptide - ENSMUSP00000135706
Ensembl peptide - ENSMUSP00000155418
Ensembl peptide - ENSMUSP00000023054
Ensembl peptide - ENSMUSP00000105249
Ensembl peptide - ENSMUSP00000132391
Ensembl peptide - ENSMUSP00000134838
Ensembl peptide - ENSMUSP00000134938
Ensembl peptide - ENSMUSP00000135011
Ensembl peptide - ENSMUSP00000135027
Ensembl peptide - ENSMUSP00000135079
Ensembl peptide - ENSMUSP00000135358
Ensembl peptide - ENSMUSP00000135502
Ensembl peptide - ENSMUSP00000135507
NCBI entrez gene - 80287     See in Manteia.
MGI - MGI:1933111
RefSeq - XM_017316808
RefSeq - NM_001160415
RefSeq - NM_001347041
RefSeq - NM_030255
RefSeq - XM_006521551
RefSeq - XM_017316806
RefSeq - XM_017316807
RefSeq Peptide - NP_001333970
RefSeq Peptide - NP_084531
RefSeq Peptide - NP_001153887
swissprot - Q99J72
swissprot - E9QMH1
swissprot - Q3TI69
swissprot - H3BJD1
swissprot - H3BJJ6
swissprot - H3BJQ3
swissprot - H3BKE5
swissprot - H3BKS1
swissprot - H3BL97
swissprot - H3BKS5
swissprot - H3BJ44
swissprot - Q3U5C5
Ensembl - ENSMUSG00000009585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6NTF7ENSG00000100298Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aicda / Q9WVE0 / Single-stranded DNA cytosine deaminase / Q9GZX7* / activation induced cytidine deaminase*ENSMUSG0000004062715
Q9WV35 / Apobec2 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2 / Q9Y235* / apolipoprotein B mRNA editing enzyme catalytic subunit 2*ENSMUSG0000004069413
P51908 / Apobec1 / apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 / P41238* / apolipoprotein B mRNA editing enzyme catalytic subunit 1*ENSMUSG0000004061312


Protein motifs (from Interpro)
Interpro ID Name
 IPR002125  Cytidine and deoxycytidylate deaminase domain
 IPR013158  APOBEC-like, N-terminal
 IPR016192  APOBEC/CMP deaminase, zinc-binding
 IPR016193  Cytidine deaminase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0010529 negative regulation of transposition ISO
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IMP
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:1903900 regulation of viral life cycle IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047844 deoxycytidine deaminase activity ISO


Pathways (from Reactome)
Pathway description
mRNA Editing: C to U Conversion
Formation of the Editosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc40a1ffe/Slc40a1+
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Gt(XN450)Byg
Genetic Background: B6.129P2-Apobec3Gt(XN450)Byg

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Gt(XN450)Byg
Genetic Background: 129P2/OlaHsd-Apobec3Gt(XN450)Byg

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Rfv3-s,H2b/H2d
Genetic Background: involves: BALB/c * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Tg(Foxp3-EGFP/icre)1aJbs/0
Genetic Background: involves: 129 * NOD/ShiLt

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Gt(XN450)Byg
Genetic Background: 129P2/OlaHsd-Apobec3Gt(XN450)Byg

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Rfv3-s,H2b/H2d
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Rfv3-s,H2b/H2b
Genetic Background: involves: A.BY * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Jag2sm/Jag2sm
Genetic Background: involves: A/Fa

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apobec3Gt(XN450)Byg/Apobec3Rfv3-s,H2b/H2d
Genetic Background: involves: BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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