ENSG00000128383


Homo sapiens

Features
Gene ID: ENSG00000128383
  
Biological name :APOBEC3A
  
Synonyms : APOBEC3A / apolipoprotein B mRNA editing enzyme catalytic subunit 3A / P31941
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 38952741
Gene end: 38992778
  
Corresponding Affymetrix probe sets: 206632_s_at (Human Genome U133 Plus 2.0 Array)   210873_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384359
Ensembl peptide - ENSP00000249116
Ensembl peptide - ENSP00000481904
NCBI entrez gene - 100913187     See in Manteia.
NCBI entrez gene - 200315     See in Manteia.
OMIM - 607109
RefSeq - NM_001270406
RefSeq - NM_145699
RefSeq Peptide - NP_001257335
RefSeq Peptide - NP_663745
swissprot - A0A0K0MJ49
swissprot - P31941
Ensembl - ENSG00000128383
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UH17 / APOBEC3B / apolipoprotein B mRNA editing enzyme catalytic subunit 3BENSG0000017975087
Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3GENSG0000023971365
Q96AK3 / APOBEC3D / apolipoprotein B mRNA editing enzyme catalytic subunit 3DENSG0000024381140
AL022318.4ENSG0000028455440
Q8IUX4 / APOBEC3F / apolipoprotein B mRNA editing enzyme catalytic subunit 3FENSG0000012839439
AICDA / Q9GZX7 / activation induced cytidine deaminaseENSG0000011173239
Q9NRW3 / APOBEC3C / apolipoprotein B mRNA editing enzyme catalytic subunit 3CENSG0000024450937
Q6NTF7 / APOBEC3H / apolipoprotein B mRNA editing enzyme catalytic subunit 3HENSG0000010029831
Q9Y235 / APOBEC2 / apolipoprotein B mRNA editing enzyme catalytic subunit 2ENSG0000012470129
P41238 / APOBEC1 / apolipoprotein B mRNA editing enzyme catalytic subunit 1ENSG0000011170126


Protein motifs (from Interpro)
Interpro ID Name
 IPR002125  Cytidine and deoxycytidylate deaminase domain
 IPR013158  APOBEC-like, N-terminal
 IPR016192  APOBEC/CMP deaminase, zinc-binding
 IPR016193  Cytidine deaminase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009972 cytidine deamination IEA
 biological_processGO:0010529 negative regulation of transposition IDA
 biological_processGO:0044356 clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0070383 DNA cytosine deamination IMP
 biological_processGO:0071466 cellular response to xenobiotic stimulus IDA
 biological_processGO:0080111 DNA demethylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004126 cytidine deaminase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047844 deoxycytidine deaminase activity IMP


Pathways (from Reactome)
Pathway description
mRNA Editing: C to U Conversion
Formation of the Editosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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