ENSG00000103363


Homo sapiens

Features
Gene ID: ENSG00000103363
  
Biological name :ELOB
  
Synonyms : ELOB / elongin B / Q15370
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 2771414
Gene end: 2777297
  
Corresponding Affymetrix probe sets: 200085_s_at (Human Genome U133 Plus 2.0 Array)   213877_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387189
Ensembl peptide - ENSP00000458443
Ensembl peptide - ENSP00000458213
Ensembl peptide - ENSP00000262306
Ensembl peptide - ENSP00000386652
NCBI entrez gene - 6923     See in Manteia.
OMIM - 600787
RefSeq - NM_207013
RefSeq - NM_007108
RefSeq Peptide - NP_009039
RefSeq Peptide - NP_996896
swissprot - Q15370
swissprot - A0A0B4J296
swissprot - I3L0M9
swissprot - B8ZZU8
Ensembl - ENSG00000103363
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elobENSDARG00000037980Danio rerio
 elongin BENSDARG00000097471Danio rerio
 ElobENSMUSG00000055839Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030891 VCB complex IBA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IDA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070449 elongin complex IBA
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Vif-mediated degradation of APOBEC3G
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
Neddylation
Regulation of expression of SLITs and ROBOs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / complex / reaction
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / reaction
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / complex
 ENSG00000183791 ELOA3 / Q8NG57 / elongin A3  / complex / reaction
 ENSG00000011007 ELOA / Q14241 / elongin A  / reaction / complex
 ENSG00000166266 CUL5 / Q93034 / cullin 5  / complex
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction / complex
 ENSG00000135766 EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1  / complex
 ENSG00000144791 LIMD1 / Q9UGP4 / LIM domains containing 1  / complex
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction / complex
 ENSG00000206181 ELOA2 / Q8IYF1 / elongin A2  / reaction / complex
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex / reaction
 ENSG00000108094 CUL2 / Q13617 / cullin 2  / complex
 ENSG00000129521 EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3  / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / reaction
 ENSG00000132128 LRRC41 / Q15345 / leucine rich repeat containing 41  / complex
 ENSG00000185338 SOCS1 / O15524 / suppressor of cytokine signaling 1  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / reaction
 ENSG00000239713 Q9HC16 / APOBEC3G / apolipoprotein B mRNA editing enzyme catalytic subunit 3G  / complex / reaction






 

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