ENSG00000108094


Homo sapiens

Features
Gene ID: ENSG00000108094
  
Biological name :CUL2
  
Synonyms : CUL2 / cullin 2 / Q13617
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p11.21
Gene start: 35008551
Gene end: 35090642
  
Corresponding Affymetrix probe sets: 203078_at (Human Genome U133 Plus 2.0 Array)   203079_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414095
Ensembl peptide - ENSP00000363886
Ensembl peptide - ENSP00000444856
Ensembl peptide - ENSP00000485986
Ensembl peptide - ENSP00000363878
Ensembl peptide - ENSP00000363880
Ensembl peptide - ENSP00000363881
Ensembl peptide - ENSP00000363883
NCBI entrez gene - 8453     See in Manteia.
OMIM - 603135
RefSeq - XM_011519747
RefSeq - NM_001198777
RefSeq - NM_001198778
RefSeq - NM_001198779
RefSeq - NM_001324375
RefSeq - NM_001324376
RefSeq - NM_003591
RefSeq - XM_011519743
RefSeq - XM_011519744
RefSeq - XM_011519745
RefSeq Peptide - NP_001185708
RefSeq Peptide - NP_001311304
RefSeq Peptide - NP_001311305
RefSeq Peptide - NP_003582
RefSeq Peptide - NP_001185706
RefSeq Peptide - NP_001185707
swissprot - Q5T2B5
swissprot - A0A140VKB1
swissprot - Q5T2B7
swissprot - A0A0A0MTN0
swissprot - Q13617
Ensembl - ENSG00000108094
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul2ENSDARG00000013965Danio rerio
 CUL2ENSGALG00000007095Gallus gallus
 Cul2ENSMUSG00000024231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL1 / Q13616 / cullin 1ENSG0000005513037
CUL3 / Q13618 / cullin 3ENSG0000003625727
CUL5 / Q93034 / cullin 5ENSG0000016626627
CUL4B / Q13620 / cullin 4BENSG0000015829027
CUL4A / Q13619 / cullin 4AENSG0000013984226


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 biological_processGO:0097193 intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030891 VCB complex IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Neddylation
Regulation of expression of SLITs and ROBOs
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / complex / reaction
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / reaction
 ENSG00000103363 ELOB / Q15370 / elongin B  / complex
 ENSG00000134086 VHL / P40337 / von Hippel-Lindau tumor suppressor  / complex
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / complex / reaction
 ENSG00000154582 ELOC / Q15369 / elongin C  / complex
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / complex / reaction
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / reaction
 ENSG00000129521 EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3  / complex
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex
 ENSG00000144791 LIMD1 / Q9UGP4 / LIM domains containing 1  / complex
 ENSG00000135766 EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / reaction






 

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