ENSG00000139842


Homo sapiens

Features
Gene ID: ENSG00000139842
  
Biological name :CUL4A
  
Synonyms : CUL4A / cullin 4A / Q13619
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 113208193
Gene end: 113267108
  
Corresponding Affymetrix probe sets: 201423_s_at (Human Genome U133 Plus 2.0 Array)   201424_s_at (Human Genome U133 Plus 2.0 Array)   227757_at (Human Genome U133 Plus 2.0 Array)   232466_at (Human Genome U133 Plus 2.0 Array)   242194_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389118
Ensembl peptide - ENSP00000364590
Ensembl peptide - ENSP00000480367
Ensembl peptide - ENSP00000481782
Ensembl peptide - ENSP00000322132
Ensembl peptide - ENSP00000364589
NCBI entrez gene - 8451     See in Manteia.
OMIM - 603137
RefSeq - XM_011537523
RefSeq - NM_001008895
RefSeq - NM_001278513
RefSeq - NM_001278514
RefSeq - NM_001354938
RefSeq - NM_001354939
RefSeq - NM_001354940
RefSeq - NM_001354941
RefSeq - NM_001354942
RefSeq - NM_003589
RefSeq Peptide - NP_001341871
RefSeq Peptide - NP_003580
RefSeq Peptide - NP_001265442
RefSeq Peptide - NP_001008895
RefSeq Peptide - NP_001265443
RefSeq Peptide - NP_001341867
RefSeq Peptide - NP_001341868
RefSeq Peptide - NP_001341869
RefSeq Peptide - NP_001341870
swissprot - Q13619
swissprot - A0A0A0MR50
swissprot - A0A087WWN2
Ensembl - ENSG00000139842
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul4aENSDARG00000096578Danio rerio
 CUL4AENSGALG00000016830Gallus gallus
 Cul4aENSMUSG00000031446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUL4B / Q13620 / cullin 4BENSG0000015829082
CUL3 / Q13618 / cullin 3ENSG0000003625739
CUL1 / Q13616 / cullin 1ENSG0000005513031
CUL2 / Q13617 / cullin 2ENSG0000010809427
CUL5 / Q93034 / cullin 5ENSG0000016626626


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006293 nucleotide-excision repair, preincision complex stabilization TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006295 nucleotide-excision repair, DNA incision, 3"-to lesion TAS
 biological_processGO:0006296 nucleotide-excision repair, DNA incision, 5"-to lesion TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030853 negative regulation of granulocyte differentiation IEA
 biological_processGO:0033683 nucleotide-excision repair, DNA incision TAS
 biological_processGO:0035019 somatic stem cell population maintenance IEA
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0051246 regulation of protein metabolic process IEA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 biological_processGO:0097193 intrinsic apoptotic signaling pathway TAS
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000001 regulation of DNA damage checkpoint IEA
 biological_processGO:2000819 regulation of nucleotide-excision repair IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / reaction / complex
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction / complex
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / reaction / complex
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction / complex
 ENSG00000049167 ERCC8 / Q13216 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit  / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / complex / reaction
 ENSG00000134574 DDB2 / Q92466 / damage specific DNA binding protein 2  / complex
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / complex / reaction
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / reaction / complex
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / reaction / complex
 ENSG00000225830 ERCC6 / P0DP91 / Q03468 / Q8N328 / ERCC excision repair 6, chromatin remodeling factor  / complex / reaction
 ENSG00000119318 P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein  / complex / reaction
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000131778 CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 like  / complex / reaction
 ENSG00000143476 DTL / Q9NZJ0 / denticleless E3 ubiquitin protein ligase homolog  / complex
 ENSG00000121022 COPS5 / Q92905 / COP9 signalosome subunit 5  / reaction
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / complex / reaction
 ENSG00000136936 XPA / P23025 / XPA, DNA damage recognition and repair factor  / complex / reaction
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / reaction / complex
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction






 

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