ENSG00000119318


Homo sapiens

Features
Gene ID: ENSG00000119318
  
Biological name :RAD23B
  
Synonyms : P54727 / RAD23B / RAD23 homolog B, nucleotide excision repair protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q31.2
Gene start: 107283137
Gene end: 107332194
  
Corresponding Affymetrix probe sets: 201222_s_at (Human Genome U133 Plus 2.0 Array)   201223_s_at (Human Genome U133 Plus 2.0 Array)   214422_at (Human Genome U133 Plus 2.0 Array)   223598_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396975
Ensembl peptide - ENSP00000415821
Ensembl peptide - ENSP00000416868
Ensembl peptide - ENSP00000350708
Ensembl peptide - ENSP00000405623
NCBI entrez gene - 5887     See in Manteia.
OMIM - 600062
RefSeq - NM_001244713
RefSeq - NM_001244724
RefSeq - NM_002874
RefSeq Peptide - NP_002865
RefSeq Peptide - NP_001231642
RefSeq Peptide - NP_001231653
swissprot - Q5W0S5
swissprot - P54727
swissprot - H0Y579
swissprot - Q5W0S4
Ensembl - ENSG00000119318
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad23bENSDARG00000021550Danio rerio
 RAD23BENSGALG00000015540Gallus gallus
 P54728ENSMUSG00000028426Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P54725 / RAD23A / RAD23 homolog A, nucleotide excision repair proteinENSG0000017926256


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR004806  UV excision repair protein Rad23
 IPR006636  Heat shock chaperonin-binding
 IPR009060  UBA-like superfamily
 IPR015360  XPC-binding domain
 IPR015940  Ubiquitin-associated domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036353  XPC-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition IDA
 biological_processGO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0070911 global genome nucleotide-excision repair TAS
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0071942 XPC complex IDA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA


Pathways (from Reactome)
Pathway description
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Josephin domain DUBs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000134574 DDB2 / Q92466 / damage specific DNA binding protein 2  / complex / reaction
 ENSG00000154767 XPC / Q01831 / XPC complex subunit, DNA damage recognition and repair factor  / reaction / complex
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex / reaction
 ENSG00000066427 ATXN3 / P54252 / ataxin 3  / reaction / complex
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / complex / reaction
 ENSG00000131778 CHD1L / Q86WJ1 / chromodomain helicase DNA binding protein 1 like  / complex / reaction
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex
 ENSG00000184900 SUMO3 / P55854 / small ubiquitin-like modifier 3  / complex
 ENSG00000143799 PARP1 / P09874 / poly(ADP-ribose) polymerase 1  / reaction / complex
 ENSG00000147400 CETN2 / P41208 / centrin 2  / complex / reaction
 ENSG00000136936 XPA / P23025 / XPA, DNA damage recognition and repair factor  / complex / reaction






 

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