ENSMUSG00000028426


Mus musculus

Features
Gene ID: ENSMUSG00000028426
  
Biological name :Rad23b
  
Synonyms : P54728 / Rad23b / UV excision repair B
  
Possible biological names infered from orthology : P54727 / RAD23 homolog B, nucleotide excision repair protein
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B3
Gene start: 55350043
Gene end: 55392237
  
Corresponding Affymetrix probe sets: 10505092 (MoGene1.0st)   1424222_s_at (Mouse Genome 430 2.0 Array)   1450903_at (Mouse Genome 430 2.0 Array)   1455420_at (Mouse Genome 430 2.0 Array)   1456822_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030134
NCBI entrez gene - 19359     See in Manteia.
MGI - MGI:105128
RefSeq - NM_009011
RefSeq Peptide - NP_033037
swissprot - P54728
Ensembl - ENSMUSG00000028426
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad23bENSDARG00000021550Danio rerio
 RAD23BENSGALG00000015540Gallus gallus
 P54727ENSG00000119318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P54726 / Rad23a / RAD23 homolog A, nucleotide excision repair protein / P54725*ENSMUSG0000000381355


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR004806  UV excision repair protein Rad23
 IPR006636  Heat shock chaperonin-binding
 IPR009060  UBA-like superfamily
 IPR015360  XPC-binding domain
 IPR015940  Ubiquitin-associated domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036353  XPC-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0048568 embryonic organ development IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0071942 XPC complex IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001349 excessive tearing "an unusually high amount of fluid secreted by the lacrimal glands, often resulting in overflow of fluid from the eye" [hdene:Howard Dene, Mouse Genome Informatics Curator, J:38104]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001711 abnormal placenta 
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0006167 eyelid edema "an abnormal accumulation of fluid in the eyelid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Nle1l11Jus4/Nle1l11Jus4
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / complex
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000002109 Ddb2 / Q99J79 / DNA damage-binding protein 2 / Q92466* / damage specific DNA binding protein 2*  / reaction / complex
 ENSMUSG00000028329 Xpa / Q64267 / xeroderma pigmentosum, complementation group A / P23025* / XPA, DNA damage recognition and repair factor*  / complex / reaction
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / reaction / complex
 ENSMUSG00000031347 Cetn2 / Q9R1K9 / Centrin-2 / P41208*  / reaction / complex
 ENSMUSG00000028089 Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*  / reaction / complex
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex






 

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