ENSMUSG00000003813


Mus musculus

Features
Gene ID: ENSMUSG00000003813
  
Biological name :Rad23a
  
Synonyms : P54726 / Rad23a / RAD23 homolog A, nucleotide excision repair protein
  
Possible biological names infered from orthology : P54725
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 84834019
Gene end: 84840665
  
Corresponding Affymetrix probe sets: 10580210 (MoGene1.0st)   1422964_at (Mouse Genome 430 2.0 Array)   1437697_at (Mouse Genome 430 2.0 Array)   1453623_a_at (Mouse Genome 430 2.0 Array)   1455391_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003911
Ensembl peptide - ENSMUSP00000105383
Ensembl peptide - ENSMUSP00000114431
Ensembl peptide - ENSMUSP00000115664
NCBI entrez gene - 19358     See in Manteia.
MGI - MGI:105126
RefSeq - XM_011248328
RefSeq - NM_001297606
RefSeq - NM_001297607
RefSeq - NM_009010
RefSeq - XM_011248327
RefSeq Peptide - NP_033036
RefSeq Peptide - NP_001284536
RefSeq Peptide - NP_001284535
swissprot - F6YL88
swissprot - Q3TN85
swissprot - P54726
swissprot - Q8CAP3
Ensembl - ENSMUSG00000003813
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rad23aaENSDARG00000020001Danio rerio
 RAD23AENSGALG00000033532Gallus gallus
 P54725ENSG00000179262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*ENSMUSG0000002842663


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR004806  UV excision repair protein Rad23
 IPR006636  Heat shock chaperonin-binding
 IPR009060  UBA-like superfamily
 IPR015360  XPC-binding domain
 IPR015940  Ubiquitin-associated domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036353  XPC-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IGI
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gasttm1Lcs/Gasttm1Lcs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rad23atm1(HBB)Laat/Rad23atm1(HBB)Laat
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Rad23atm2(HBB)Laat/Rad23atm2(HBB)Laat
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Rad23atm1Jhjh/Rad23atm1Jhjh,Rad23btm1Gvh/Rad23b+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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