ENSMUSG00000002109


Mus musculus

Features
Gene ID: ENSMUSG00000002109
  
Biological name :Ddb2
  
Synonyms : Ddb2 / DNA damage-binding protein 2 / Q99J79
  
Possible biological names infered from orthology : damage specific DNA binding protein 2 / Q92466
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 91211572
Gene end: 91236982
  
Corresponding Affymetrix probe sets: 10484999 (MoGene1.0st)   1425706_a_at (Mouse Genome 430 2.0 Array)   1436680_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106984
Ensembl peptide - ENSMUSP00000028696
NCBI entrez gene - 107986     See in Manteia.
MGI - MGI:1355314
RefSeq - NM_028119
RefSeq Peptide - NP_082395
swissprot - A2AGR6
swissprot - Q99J79
Ensembl - ENSMUSG00000002109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddb2ENSDARG00000041140Danio rerio
 DDB2ENSGALG00000008218Gallus gallus
 DDB2ENSG00000134574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR033312  DNA damage-binding protein 2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006290 pyrimidine dimer repair IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009411 response to UV IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035518 histone H2A monoubiquitination IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0070914 UV-damage excision repair IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001203 skin irradiation sensitivity "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ddb2tm1Vri/Ddb2tm1Vri
Genetic Background: involves: 129P2/Ola * SKH1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh
Genetic Background: involves: 129S6/SvEvTac

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Trp53tm1Adv/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ddb2tm1Pra/Ddb2+
Genetic Background: involves: C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Adv/Trp53+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ddb2tm1Pra/Ddb2+
Genetic Background: involves: C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ddb2tm1Vri/Ddb2tm1Vri
Genetic Background: involves: 129P2/Ola * SKH1

Allelic Composition: Ddb2tm1Vri/Ddb2+
Genetic Background: involves: 129P2/Ola * SKH1

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh
Genetic Background: involves: 129S6/SvEvTac

 MP:0004501 increased incidence of UV-induced tumors "higher than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ece1tm1Reh/Ece1tm1Reh
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000031347 Cetn2 / Q9R1K9 / Centrin-2 / P41208*  / reaction / complex
 ENSMUSG00000028426 P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*  / reaction / complex
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSMUSG00000028329 Xpa / Q64267 / xeroderma pigmentosum, complementation group A / P23025* / XPA, DNA damage recognition and repair factor*  / reaction / complex
 ENSMUSG00000028089 Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*  / complex / reaction
 ENSMUSG00000028514 Usp24 / B1AY13 / ubiquitin specific peptidase 24 / Q9UPU5*  / complex






 

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