ENSMUSG00000031347


Mus musculus

Features
Gene ID: ENSMUSG00000031347
  
Biological name :Cetn2
  
Synonyms : Centrin-2 / Cetn2 / Q9R1K9
  
Possible biological names infered from orthology : P41208
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A7.3
Gene start: 72913532
Gene end: 72918411
  
Corresponding Affymetrix probe sets: 10604974 (MoGene1.0st)   1418579_at (Mouse Genome 430 2.0 Array)   1438647_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000110198
Ensembl peptide - ENSMUSP00000117704
Ensembl peptide - ENSMUSP00000033713
Ensembl peptide - ENSMUSP00000110197
NCBI entrez gene - 26370     See in Manteia.
MGI - MGI:1347085
RefSeq - NM_019405
RefSeq Peptide - NP_062278
swissprot - B1AUQ7
swissprot - Q9R1K9
swissprot - Z4YJH1
Ensembl - ENSMUSG00000031347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cetn2ENSDARG00000101510Danio rerio
 CETN2ENSGALG00000007510Gallus gallus
 CETN2ENSG00000147400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cetn1 / P41209 / Centrin-1 / Q12798*ENSMUSG0000005099681
Cetn4 / Q8K4K1 / Centrin-4 ENSMUSG0000004503170
Cetn3 / O35648 / Centrin-3 / O15182*ENSMUSG0000002153751
Efcab2 / Q9CQ46 / EF-hand calcium-binding domain-containing protein 2 / Q5VUJ9* / EF-hand calcium binding domain 2*ENSMUSG0000002649527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007099 centriole replication IEA
 biological_processGO:0007283 spermatogenesis IEP
 biological_processGO:0032465 regulation of cytokinesis IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0071942 XPC complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IDA
 molecular_functionGO:0032795 heterotrimeric G-protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
SUMOylation of DNA damage response and repair proteins
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011281 abnormal olfactory epithelium cilium morphology "any structural anomaly of the cilia of the epithelial cells that line the interior of the nose" [MGI:smb]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0013907 abnormal cerebrospinal fluid flow "any anomaly in the dynamic process by which CSF circulates from the sites of secretion to the sites of absorption according to a unidirectional rostrocaudal flow in ventricular cavities and a multidirectional flow in subarachnoid spaces; CSF produced by the choroid plexuses in the lateral ventricles travels through interventricular foramina to the third ventricle, and then the fourth ventricle via the cerebral aqueduct and finally to the subarachnoid spaces via the median aperture (foramen of Magendie) of the fourth ventricle; in the cranial subarachnoid space, CSF circulates rostrally to the villous sites of absorption or caudally to the spinal subarachnoid space; CSF circulation through the ventricular system is driven by motile cilia on ependymal cells of the brain; CSF flow is pulsatile, corresponding to the systolic pulse wave in choroidal arteries; additional factors such as respiratory waves, the subject s posture, jugular venous pressure and physical effort also modulate CSF flow dynamics and pressure" [MGI:Anna, PMID:22100360, PMID:24229449]
Show

Allelic Composition: Adcy4tm1.1Dek/Adcy4tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / reaction / complex
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000026496 Parp1 / poly (ADP-ribose) polymerase family, member 1 / P09874* / poly(ADP-ribose) polymerase 1*  / complex / reaction
 ENSMUSG00000002109 Ddb2 / Q99J79 / DNA damage-binding protein 2 / Q92466* / damage specific DNA binding protein 2*  / reaction / complex
 ENSMUSG00000028329 Xpa / Q64267 / xeroderma pigmentosum, complementation group A / P23025* / XPA, DNA damage recognition and repair factor*  / complex / reaction
 ENSMUSG00000020265 Sumo3 / Q9Z172 / small ubiquitin-like modifier 3 / P55854*  / reaction / complex
 ENSMUSG00000030094 Xpc / P51612 / xeroderma pigmentosum, complementation group C / Q01831* / XPC complex subunit, DNA damage recognition and repair factor*  / complex / reaction
 ENSMUSG00000028426 P54728 / Rad23b / UV excision repair B / P54727* / RAD23 homolog B, nucleotide excision repair protein*  / complex / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex
 ENSMUSG00000028089 Chd1l / Q9CXF7 / Chromodomain-helicase-DNA-binding protein 1-like / Q86WJ1*  / reaction / complex






 

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