ENSG00000130725


Homo sapiens

Features
Gene ID: ENSG00000130725
  
Biological name :UBE2M
  
Synonyms : P61081 / UBE2M / ubiquitin conjugating enzyme E2 M
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.43
Gene start: 58555712
Gene end: 58558960
  
Corresponding Affymetrix probe sets: 203109_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468940
Ensembl peptide - ENSP00000469855
Ensembl peptide - ENSP00000253023
NCBI entrez gene - 9040     See in Manteia.
OMIM - 603173
RefSeq - NM_003969
RefSeq Peptide - NP_003960
swissprot - A0A024R4T4
swissprot - M0QX69
swissprot - M0QYI6
swissprot - P61081
Ensembl - ENSG00000130725
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBE2MENSDARG00000101521Danio rerio
 Ube2mENSMUSG00000005575Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2F / Q969M7 / ubiquitin conjugating enzyme E2 F (putative)ENSG0000018418232
UBE2F-SCLY / UBE2F-SCLY readthrough (NMD candidate)ENSG0000025898419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045116 protein neddylation IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019788 NEDD8 transferase activity TAS


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling activates SMADs
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / reaction / complex
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / reaction / complex
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / reaction / complex
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex / reaction
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / reaction / complex
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / reaction / complex
 ENSG00000112659 CUL9 / Q8IWT3 / cullin 9  / reaction / complex
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction
 ENSG00000159593 NAE1 / Q13564 / NEDD8 activating enzyme E1 subunit 1  / complex / reaction
 ENSG00000163513 P37173 / TGFBR2 / transforming growth factor beta receptor 2  / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000144744 UBA3 / Q8TBC4 / ubiquitin like modifier activating enzyme 3  / reaction / complex






 

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