ENSG00000159593


Homo sapiens

Features
Gene ID: ENSG00000159593
  
Biological name :NAE1
  
Synonyms : NAE1 / NEDD8 activating enzyme E1 subunit 1 / Q13564
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.1
Gene start: 66802875
Gene end: 66873256
  
Corresponding Affymetrix probe sets: 202268_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464119
Ensembl peptide - ENSP00000462937
Ensembl peptide - ENSP00000463546
Ensembl peptide - ENSP00000290810
Ensembl peptide - ENSP00000351990
Ensembl peptide - ENSP00000368776
Ensembl peptide - ENSP00000377637
Ensembl peptide - ENSP00000454471
Ensembl peptide - ENSP00000454506
Ensembl peptide - ENSP00000455562
Ensembl peptide - ENSP00000455967
Ensembl peptide - ENSP00000456564
Ensembl peptide - ENSP00000456847
Ensembl peptide - ENSP00000462040
NCBI entrez gene - 8883     See in Manteia.
OMIM - 603385
RefSeq - XM_011523422
RefSeq - NM_001018159
RefSeq - NM_001018160
RefSeq - NM_001286500
RefSeq - NM_003905
RefSeq - XM_005256215
RefSeq Peptide - NP_003896
RefSeq Peptide - NP_001018169
RefSeq Peptide - NP_001018170
RefSeq Peptide - NP_001273429
swissprot - Q13564
swissprot - H3BMN8
swissprot - H3BMR3
swissprot - H3BQ16
swissprot - H3BQW6
swissprot - H3BS69
swissprot - J3KRK3
swissprot - H3BSS8
swissprot - J3KTE3
swissprot - J3QLH4
swissprot - J3QRA5
Ensembl - ENSG00000159593
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nae1ENSDARG00000011301Danio rerio
 NAE1ENSGALG00000038957Gallus gallus
 Nae1ENSMUSG00000031878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR030667  NEDD8-activating enzyme E1 regulatory subunit APP-BP1
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0033314 mitotic DNA replication checkpoint IDA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043523 regulation of neuron apoptotic process IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045116 protein neddylation IEA
 biological_processGO:0051402 neuron apoptotic process IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0019781 NEDD8 activating enzyme activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / complex / reaction
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex / reaction
 ENSG00000184182 UBE2F / Q969M7 / ubiquitin conjugating enzyme E2 F (putative)  / complex / reaction
 ENSG00000144744 UBA3 / Q8TBC4 / ubiquitin like modifier activating enzyme 3  / complex






 

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