ENSG00000144744


Homo sapiens

Features
Gene ID: ENSG00000144744
  
Biological name :UBA3
  
Synonyms : Q8TBC4 / UBA3 / ubiquitin like modifier activating enzyme 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.1
Gene start: 69054730
Gene end: 69080408
  
Corresponding Affymetrix probe sets: 209115_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486366
Ensembl peptide - ENSP00000419077
Ensembl peptide - ENSP00000486985
Ensembl peptide - ENSP00000340041
Ensembl peptide - ENSP00000354340
Ensembl peptide - ENSP00000400294
Ensembl peptide - ENSP00000417547
NCBI entrez gene - 9039     See in Manteia.
OMIM - 603172
RefSeq - XM_011534211
RefSeq - NM_003968
RefSeq - NM_198195
RefSeq - XM_011534210
RefSeq Peptide - NP_937838
RefSeq Peptide - NP_003959
swissprot - F8WF86
swissprot - Q8TBC4
swissprot - F8W8D4
swissprot - F8WAT6
swissprot - A0A0D9SF81
Ensembl - ENSG00000144744
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba3ENSDARG00000057987Danio rerio
 UBA3ENSGALG00000013410Gallus gallus
 Uba3ENSMUSG00000030061Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR014929  E2 binding
 IPR030468  NEDD8-activating enzyme E1 catalytic subunit
 IPR033127  Ubiquitin-activating enzyme E1, Cys active site
 IPR035985  Ubiquitin-activating enzyme
 IPR037078  NEDD8-activating enzyme E1 catalytic subunit, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007113 endomitotic cell cycle IEA
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045116 protein neddylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0016881 acid-amino acid ligase activity IEA
 molecular_functionGO:0016922 nuclear receptor binding IEA
 molecular_functionGO:0019781 NEDD8 activating enzyme activity IEA
 molecular_functionGO:0019788 NEDD8 transferase activity TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex / reaction
 ENSG00000159593 NAE1 / Q13564 / NEDD8 activating enzyme E1 subunit 1  / complex
 ENSG00000184182 UBE2F / Q969M7 / ubiquitin conjugating enzyme E2 F (putative)  / complex / reaction
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / complex / reaction






 

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