ENSMUSG00000005575


Mus musculus

Features
Gene ID: ENSMUSG00000005575
  
Biological name :Ube2m
  
Synonyms : P61082 / Ube2m / ubiquitin-conjugating enzyme E2M
  
Possible biological names infered from orthology : P61081
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 13035120
Gene end: 13038275
  
Corresponding Affymetrix probe sets: 10560070 (MoGene1.0st)   1424345_s_at (Mouse Genome 430 2.0 Array)   1425858_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005714
Ensembl peptide - ENSMUSP00000120234
Ensembl peptide - ENSMUSP00000122638
Ensembl peptide - ENSMUSP00000132604
NCBI entrez gene - 22192     See in Manteia.
MGI - MGI:108278
RefSeq - NM_001168469
RefSeq - NM_001243968
RefSeq - NM_145578
RefSeq Peptide - NP_001161941
RefSeq Peptide - NP_001230897
RefSeq Peptide - NP_663553
swissprot - P61082
swissprot - G5E919
swissprot - F6WMC0
swissprot - F7CDT0
Ensembl - ENSMUSG00000005575
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBE2MENSDARG00000101521Danio rerio
 UBE2MENSG00000130725Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube2f / Q9CY34 / ubiquitin-conjugating enzyme E2F (putative) / Q969M7*ENSMUSG0000003434332


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006464 cellular protein modification process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045116 protein neddylation ISO
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019788 NEDD8 transferase activity IEA


Pathways (from Reactome)
Pathway description
TGF-beta receptor signaling activates SMADs
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Txniptm1b(EUCOMM)Hmgu/Txniptm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Txniptm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / reaction
 ENSMUSG00000032440 Q62312 / Tgfbr2 / transforming growth factor, beta receptor II / P37173* / transforming growth factor beta receptor 2*  / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / reaction
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / complex
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex
 ENSMUSG00000031878 Nae1 / Q8VBW6 / NEDD8-activating enzyme E1 regulatory subunit / Q13564* / NEDD8 activating enzyme E1 subunit 1*  / reaction / complex
 ENSMUSG00000040327 Cul9 / cullin 9 / Q8IWT3*  / reaction / complex
 ENSMUSG00000030061 Uba3 / Q8C878 / ubiquitin-like modifier activating enzyme 3 / Q8TBC4*  / reaction / complex






 

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