ENSMUSG00000040327


Mus musculus

Features
Gene ID: ENSMUSG00000040327
  
Biological name :Cul9
  
Synonyms : Cul9 / cullin 9
  
Possible biological names infered from orthology : Q8IWT3
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 46500572
Gene end: 46546388
  
Corresponding Affymetrix probe sets: 10451322 (MoGene1.0st)   1427620_at (Mouse Genome 430 2.0 Array)   1439866_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067736
Ensembl peptide - ENSMUSP00000138418
NCBI entrez gene - 78309     See in Manteia.
MGI - MGI:1925559
RefSeq - XM_011246723
RefSeq - NM_001081335
RefSeq - XM_006525135
RefSeq - XM_006525136
RefSeq - XM_011246722
RefSeq Peptide - NP_001074804
swissprot - S4R1Y1
swissprot - E9QP09
Ensembl - ENSMUSG00000040327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CUL9ENSG00000112659Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul7 / Q8VE73 / Cullin-7 / Q14999*ENSMUSG0000003854536
Zzef1 / Q5SSH7 / zinc finger, ZZ-type with EF hand domain 1 / O43149* / zinc finger ZZ-type and EF-hand domain containing 1*ENSMUSG0000005567016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR001841  Zinc finger, RING-type
 IPR002867  IBR domain
 IPR004939  APC10/DOC domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014722  Ribosomal protein L2, domain 2
 IPR016024  Armadillo-type fold
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR017907  Zinc finger, RING-type, conserved site
 IPR019559  Cullin protein, neddylation domain
 IPR021097  CPH domain
 IPR031222  Cullin-9
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007088 regulation of mitotic nuclear division IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cul9tm1.2Yxi/Cul9+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cul9tm1.2Yxi/Cul9+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Emx1tm1(cre)Krj/Emx1+,Numbtm1Ynj/Numbtm1Ynj,Numbltm1Wmz/Numbltm1Wmz
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * CD-1

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0003364 insulinoma "a pancreatic islet beta cell adenoma that secretes excess insulin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010320 increased pituitary gland tumor incidence "greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul9tm1.2Yxi/Cul9+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Col2a1Rgsc856/Col2a1Rgsc856
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Cul9tm1.2Yxi/Cul9+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

Allelic Composition: Cul9tm1.2Yxi/Cul9tm1.2Yxi,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex / reaction
 ENSMUSG00000041117 Ccdc8 / D3YZV8 / Coiled-coil domain-containing / Q9H0W5* / coiled-coil domain containing 8*  / reaction / complex
 ENSMUSG00000026211 Obsl1 / D3YYU8 / Obscurin-like protein 1 / O75147* / obscurin like 1*  / reaction / complex
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000038545 Cul7 / Q8VE73 / Cullin-7 / Q14999*  / complex / reaction






 

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