ENSMUSG00000038545


Mus musculus

Features
Gene ID: ENSMUSG00000038545
  
Biological name :Cul7
  
Synonyms : Cul7 / Cullin-7 / Q8VE73
  
Possible biological names infered from orthology : Q14999
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: C
Gene start: 46650337
Gene end: 46664364
  
Corresponding Affymetrix probe sets: 10445574 (MoGene1.0st)   1417039_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049128
Ensembl peptide - ENSMUSP00000119393
Ensembl peptide - ENSMUSP00000116133
NCBI entrez gene - 66515     See in Manteia.
MGI - MGI:1913765
RefSeq - NM_025611
RefSeq Peptide - NP_079887
swissprot - A9C491
swissprot - F6Q1R4
swissprot - E9Q6H4
swissprot - Q8VE73
Ensembl - ENSMUSG00000038545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CUL7ENSG00000044090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul9 / cullin 9 / Q8IWT3*ENSMUSG0000004032754
Zzef1 / Q5SSH7 / zinc finger, ZZ-type with EF hand domain 1 / O43149* / zinc finger ZZ-type and EF-hand domain containing 1*ENSMUSG0000005567016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR004939  APC10/DOC domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR014722  Ribosomal protein L2, domain 2
 IPR016024  Armadillo-type fold
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR019559  Cullin protein, neddylation domain
 IPR021097  CPH domain
 IPR031223  Cullin-7
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0000281 mitotic cytokinesis ISO
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001837 epithelial to mesenchymal transition ISO
 biological_processGO:0001890 placenta development ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0007088 regulation of mitotic nuclear division IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0045601 regulation of endothelial cell differentiation NAS
 biological_processGO:0050775 positive regulation of dendrite morphogenesis ISO
 cellular_componentGO:0005622 intracellular IC
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:1990393 3M complex IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Otx2tm3Tlam/Otx2tm3Tlam
Genetic Background: 129/Sv-Otx2tm3Tlam

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / reaction / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000026211 Obsl1 / D3YYU8 / Obscurin-like protein 1 / O75147* / obscurin like 1*  / complex
 ENSMUSG00000041117 Ccdc8 / D3YZV8 / Coiled-coil domain-containing / Q9H0W5* / coiled-coil domain containing 8*  / complex
 ENSMUSG00000040327 Cul9 / cullin 9 / Q8IWT3*  / complex / reaction






 

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