ENSMUSG00000051355


Mus musculus

Features
Gene ID: ENSMUSG00000051355
  
Biological name :Commd1
  
Synonyms : Commd1 / COMM domain-containing protein 1 / Q8K4M5
  
Possible biological names infered from orthology : copper metabolism domain containing 1 / Q8N668
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.2
Gene start: 22896136
Gene end: 22982382
  
Corresponding Affymetrix probe sets: 10384662 (MoGene1.0st)   1424121_at (Mouse Genome 430 2.0 Array)   1424122_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124719
Ensembl peptide - ENSMUSP00000053606
Ensembl peptide - ENSMUSP00000065079
Ensembl peptide - ENSMUSP00000090958
NCBI entrez gene - 17846     See in Manteia.
MGI - MGI:109474
RefSeq - NM_144514
RefSeq - XM_006514563
RefSeq - XM_006514564
RefSeq - XM_017314316
RefSeq Peptide - NP_653097
swissprot - Q8K4M5
swissprot - G8JL54
swissprot - A2RSF1
swissprot - F7BZY0
swissprot - Q8VI86
Ensembl - ENSMUSG00000051355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 commd1ENSDARG00000031203Danio rerio
 COMMD1ENSGALG00000008931Gallus gallus
 COMMD1ENSG00000173163Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm28048 / COMMD1* / Q8N668* / copper metabolism domain containing 1*ENSMUSG0000009865052


Protein motifs (from Interpro)
Interpro ID Name
 IPR017920  COMM domain
 IPR033776  COMMD1 N-terminal domain
 IPR037351  COMM domain-containing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006878 cellular copper ion homeostasis ISO
 biological_processGO:0006893 Golgi to plasma membrane transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0034383 low-density lipoprotein particle clearance IMP
 biological_processGO:0042632 cholesterol homeostasis ISO
 biological_processGO:0048227 plasma membrane to endosome transport ISO
 biological_processGO:0055070 copper ion homeostasis IEA
 biological_processGO:0097006 regulation of plasma lipoprotein particle levels IMP
 biological_processGO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway IMP
 biological_processGO:1902306 negative regulation of sodium ion transmembrane transport ISO
 biological_processGO:1904109 positive regulation of cholesterol import IMP
 biological_processGO:1905751 positive regulation of endosome to plasma membrane protein transport IMP
 biological_processGO:2000009 negative regulation of protein localization to cell surface ISO
 biological_processGO:2000010 positive regulation of protein localization to cell surface IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex ISS
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0005507 copper ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISO
 molecular_functionGO:0019871 sodium channel inhibitor activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO
 molecular_functionGO:0070300 phosphatidic acid binding ISO
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISO


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003066 increased hepatic copper content "a greater accumulation of copper in the liver tissue compared to controls" [RGD:Rat Genome Database submission]
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Allelic Composition: Arl6ip5tm1Tnkk/Arl6ip5+
Genetic Background: either: B6.Cg-Arl6ip5tm1Tnkk or (involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj)

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0006301 abnormal mesenchyme morphology "abnormality in the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems." [J:120305, mnk:Michelle Knowlton_MGI Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005575 Ube2m / P61082 / ubiquitin-conjugating enzyme E2M / P61081*  / complex
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex
 ENSMUSG00000020114 Cand1 / Q6ZQ38 / Cullin-associated NEDD8-dissociated protein 1 / Q86VP6* / cullin associated and neddylation dissociated 1*  / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / reaction / complex
 ENSMUSG00000025917 Cops5 / O35864 / COP9 signalosome complex subunit 5 / Q92905* / COP9 signalosome subunit 5*  / reaction
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000034343 Ube2f / Q9CY34 / ubiquitin-conjugating enzyme E2F (putative) / Q969M7*  / complex
 ENSMUSG00000048787 Q8K0V2 / Dcun1d3 / DCN1-like protein 3 / Q8IWE4* / defective in cullin neddylation 1 domain containing 3*  / reaction / complex
 ENSMUSG00000031095 Cul4b / A2A432 / Cullin-4B / Q13620*  / complex / reaction
 ENSMUSG00000024740 Ddb1 / Q3U1J4 / DNA damage-binding protein 1 / Q16531* / damage specific DNA binding protein 1*  / complex / reaction
 ENSMUSG00000031446 Cul4a / Q3TCH7 / Cullin-4A / Q13619*  / reaction / complex
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex / reaction






 

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