ENSMUSG00000004364


Mus musculus

Features
Gene ID: ENSMUSG00000004364
  
Biological name :Cul3
  
Synonyms : Cul3 / Cullin-3 / Q9JLV5
  
Possible biological names infered from orthology : Q13618
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 80264923
Gene end: 80340480
  
Corresponding Affymetrix probe sets: 10356001 (MoGene1.0st)   1422794_at (Mouse Genome 430 2.0 Array)   1422795_at (Mouse Genome 430 2.0 Array)   1434717_at (Mouse Genome 430 2.0 Array)   1434718_at (Mouse Genome 430 2.0 Array)   1450756_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130010
Ensembl peptide - ENSMUSP00000131891
Ensembl peptide - ENSMUSP00000132485
Ensembl peptide - ENSMUSP00000126630
Ensembl peptide - ENSMUSP00000130738
NCBI entrez gene - 26554     See in Manteia.
MGI - MGI:1347360
RefSeq - XM_006496498
RefSeq - NM_001313728
RefSeq - NM_016716
RefSeq - XM_006496497
RefSeq Peptide - NP_057925
RefSeq Peptide - NP_001300657
swissprot - F6R0N8
swissprot - Q9JLV5
swissprot - F6UY44
swissprot - F6ZZK0
swissprot - E9Q4T8
Ensembl - ENSMUSG00000004364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cul3aENSDARG00000038967Danio rerio
 cul3bENSDARG00000100108Danio rerio
 CUL3ENSGALG00000005108Gallus gallus
 CUL3ENSG00000036257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cul4a / Q3TCH7 / Cullin-4A / Q13619*ENSMUSG0000003144639
Cul4b / A2A432 / Cullin-4B / Q13620*ENSMUSG0000003109538
Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*ENSMUSG0000002968630
Cul2 / Q9D4H8 / Cullin-2 / Q13617*ENSMUSG0000002423126
Cul5 / cullin 5 / Q93034*ENSMUSG0000003203024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain
 IPR036317  Cullin homology domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001831 trophectodermal cellular morphogenesis IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006513 protein monoubiquitination IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0017145 stem cell division IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0040016 embryonic cleavage IMP
 biological_processGO:0043149 stress fiber assembly IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0044346 fibroblast apoptotic process IMP
 biological_processGO:0045842 positive regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0048208 COPII vesicle coating IEA
 biological_processGO:0071630 nuclear protein quality control by the ubiquitin-proteasome system IEA
 biological_processGO:0072576 liver morphogenesis IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005827 polar microtubule IEA
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 cellular_componentGO:0036126 sperm flagellum IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030332 cyclin binding IPI
 molecular_functionGO:0031208 POZ domain binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Degradation of DVL
Hedgehog on state
Regulation of RAS by GAPs
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Cul3tm1.1Jdsr/Cul3tm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cul3tm1.1Jdsr/Cul3tm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Cul3tm1Suc/Cul3+
Genetic Background: involves: C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Cul3tm1.1Jdsr/Cul3tm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Cul3tm1Jro/Cul3+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004043 abnormal pH regulation "anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005028 abnormal trophectoderm "malformed outermost layer of cells in the blastodermic vesicle, which will contact the endometrium and take part in establishing the embryo s means of nutrition" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010736 abnormal extraembryonic ectoderm morphology "any structural anomaly of the layer of the ectoderm of the extraembryonic tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mstntm1Sjl/Mstntm1Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cul3tm1.1Jdsr/Cul3tm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Wnt5a,-AcGFP)Skde/Gt(ROSA)26Sor+,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012339 hyperkalemia "excessively high concentrations of potassium in the circulating blood; may be due to renal insufficiency or to mineralocorticoid deficiency or resistance" [ISBN:0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
Show

Allelic Composition: Cul3tm1.1Arte/Cul3tm1.1Arte
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cul3tm1.1Jdsr/Cul3tm1Jro
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex / reaction
 ENSMUSG00000010376 Nedd8 / P29595 / Q15843* / neural precursor cell expressed, developmentally down-regulated 8*  / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000020114 Cand1 / Q6ZQ38 / Cullin-associated NEDD8-dissociated protein 1 / Q86VP6* / cullin associated and neddylation dissociated 1*  / complex / reaction
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex
 ENSMUSG00000031143 Ccdc22 / Q9JIG7 / Coiled-coil domain-containing protein 22 / O60826* / coiled-coil domain containing 22*  / complex / reaction
 ENSMUSG00000051355 Commd1 / Q8K4M5 / COMM domain-containing protein 1 / Q8N668* / copper metabolism domain containing 1*  / complex / reaction
 ENSMUSG00000048402 Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*  / complex / reaction
 ENSMUSG00000057522 Spop / Q6ZWS8 / Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / O43791* / speckle type BTB/POZ protein*  / complex
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / complex / reaction
 ENSMUSG00000026455 Klhl12 / Q8BZM0 / Kelch-like protein 12 / Q53G59* / kelch like family member 12*  / complex
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex
 ENSMUSG00000043881 Kbtbd7 / Q86V97* / Q8WVZ9* / KBTBD6* / kelch repeat and BTB domain containing 6* / kelch repeat and BTB domain containing 7*  / complex






 

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