ENSMUSG00000057522


Mus musculus

Features
Gene ID: ENSMUSG00000057522
  
Biological name :Spop
  
Synonyms : Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / Q6ZWS8 / Spop
  
Possible biological names infered from orthology : O43791 / speckle type BTB/POZ protein
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 95414080
Gene end: 95493406
  
Corresponding Affymetrix probe sets: 10380534 (MoGene1.0st)   1416524_at (Mouse Genome 430 2.0 Array)   1416525_at (Mouse Genome 430 2.0 Array)   1447827_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118922
Ensembl peptide - ENSMUSP00000119650
Ensembl peptide - ENSMUSP00000103350
Ensembl peptide - ENSMUSP00000103352
NCBI entrez gene - 20747     See in Manteia.
MGI - MGI:1343085
RefSeq - NM_025287
RefSeq - XM_006532692
RefSeq - NM_001359107
RefSeq Peptide - NP_001346036
RefSeq Peptide - NP_079563
swissprot - B1ATK6
swissprot - Q6ZWS8
swissprot - B1ATK7
Ensembl - ENSMUSG00000057522
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spopENSDARG00000100519Danio rerio
 SPOPENSGALG00000009939Gallus gallus
 SPOPENSG00000121067Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spopl / Q2M2N2 / Speckle-type POZ protein-like / Q6IQ16* / speckle type BTB/POZ protein like*ENSMUSG0000002677183
Gm4778ENSMUSG0000008969659
Gm10696ENSMUSG0000007442458
Q6YCH2 / Tdpoz4 / TD and POZ domain-containing protein 4 ENSMUSG0000006025657
Tdpoz2ENSMUSG0000010336257
Gm5773 / Q717B2 / predicted pseudogene 5773ENSMUSG0000006887957
Gm9117 / P0DMR6 / predicted pseudogene 9117ENSMUSG0000009582256
Gm9125 / P0DMR6 / TD and POZ domain-containing protein 1-like ENSMUSG0000009432856
Gm5286ENSMUSG0000009026855
P0DMR5 / Tdpoz1 / TD and POZ domain-containing protein 1 ENSMUSG0000009408455
Q717B4 / Tdpoz3 / TD and POZ domain-containing protein 3 ENSMUSG0000005800553
Tdpoz5 / TD and POZ domain containing 5ENSMUSG0000009416351
Gm10697ENSMUSG0000009525151
Gm37596ENSMUSG0000010335051
Gm4858 / TD and POZ domain containing-like isoform 1 ENSMUSG0000009687939
Kbtbd4 / Q8R179 / Kelch repeat and BTB domain-containing protein 4 / Q9NVX7* / kelch repeat and BTB domain containing 4*ENSMUSG0000000550515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR034089  SPOP, C-terminal BACK-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030162 regulation of proteolysis IBA
 biological_processGO:0042593 glucose homeostasis IGI
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
 biological_processGO:2000676 positive regulation of type B pancreatic cell apoptotic process IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex ISO
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002544 brachydactyly "abnormally short digits" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003898 abnormal QRS complex "anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarise prior to their contraction" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004634 short metacarpal bones "reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004635 short metatarsal bones "reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1+,SpopGt(BGB118)Byg/Spop+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Naipctm1Kmma/Naipctm1Kmma,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: B6.Cg-Lyz2tm1(cre)Ifo Naipctm1Kmma

Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Paip2tm1.2Nso/Paip2tm1.2Nso,Paip2btm1.2Nso/Paip2btm1.2Nso
Genetic Background: B6.129-Paip2btm1.2Nso Paip2tm1.2Nso

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Spns2tm1b(KOMP)Wtsi/Spns2tm1b(KOMP)Wtsi
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd-Spns2tm1b(KOMP)Wtsi/WtsiH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048402 Gli2 / Q0VGT2 / Zinc finger protein GLI2 / P10070* / GLI family zinc finger 2*  / complex / reaction
 ENSMUSG00000021318 Gli3 / Q61602 / Transcriptional activator GLI3 Transcriptional repressor GLI3R / P10071* / GLI family zinc finger 3*  / complex / reaction
 ENSMUSG00000004364 Cul3 / Q9JLV5 / Cullin-3 / Q13618*  / complex
 ENSMUSG00000026771 Spopl / Q2M2N2 / Speckle-type POZ protein-like / Q6IQ16* / speckle type BTB/POZ protein like*  / complex
 ENSMUSG00000057522 Spop / Q6ZWS8 / Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / O43791* / speckle type BTB/POZ protein*  / complex
 ENSMUSG00000022400 Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*  / complex






 

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