ENSMUSG00000026771


Mus musculus

Features
Gene ID: ENSMUSG00000026771
  
Biological name :Spopl
  
Synonyms : Q2M2N2 / Speckle-type POZ protein-like / Spopl
  
Possible biological names infered from orthology : Q6IQ16 / speckle type BTB/POZ protein like
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 23506220
Gene end: 23572106
  
Corresponding Affymetrix probe sets: 10480445 (MoGene1.0st)   1429121_at (Mouse Genome 430 2.0 Array)   1435274_at (Mouse Genome 430 2.0 Array)   1459560_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142047
Ensembl peptide - ENSMUSP00000142158
Ensembl peptide - ENSMUSP00000114974
Ensembl peptide - ENSMUSP00000141519
NCBI entrez gene - 76857     See in Manteia.
MGI - MGI:1924107
RefSeq - XM_017319324
RefSeq - NM_001165997
RefSeq - NM_001165998
RefSeq - NM_029773
RefSeq - XM_006498412
RefSeq - XM_006498414
RefSeq - XM_006498417
RefSeq - XM_017319323
RefSeq Peptide - NP_084049
RefSeq Peptide - NP_001159469
RefSeq Peptide - NP_001159470
swissprot - A0A0A6YWE7
swissprot - Q2M2N2
swissprot - A0A0A6YXL9
swissprot - A0A0A6YXV6
Ensembl - ENSMUSG00000026771
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5BL35ENSDARG00000010563Danio rerio
 SPOPLENSGALG00000012380Gallus gallus
 SPOPLENSG00000144228Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spop / Q6ZWS8 / Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / O43791* / speckle type BTB/POZ protein*ENSMUSG0000005752279
Gm4778ENSMUSG0000008969651
Gm10696ENSMUSG0000007442450
Q6YCH2 / Tdpoz4 / TD and POZ domain-containing protein 4 ENSMUSG0000006025650
Gm5773 / Q717B2 / predicted pseudogene 5773ENSMUSG0000006887949
Tdpoz2ENSMUSG0000010336249
Gm9117 / P0DMR6 / predicted pseudogene 9117ENSMUSG0000009582248
P0DMR5 / Tdpoz1 / TD and POZ domain-containing protein 1 ENSMUSG0000009408448
Gm5286ENSMUSG0000009026848
Gm9125 / P0DMR6 / TD and POZ domain-containing protein 1-like ENSMUSG0000009432848
Q717B4 / Tdpoz3 / TD and POZ domain-containing protein 3 ENSMUSG0000005800547
Gm10697ENSMUSG0000009525145
Gm37596ENSMUSG0000010335045
Tdpoz5 / TD and POZ domain containing 5ENSMUSG0000009416345
Gm4858 / TD and POZ domain containing-like isoform 1 ENSMUSG0000009687934
Kbtbd4 / Q8R179 / Kelch repeat and BTB domain-containing protein 4 / Q9NVX7* / kelch repeat and BTB domain containing 4*ENSMUSG0000000550515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR034089  SPOP, C-terminal BACK-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030162 regulation of proteolysis IBA
 biological_processGO:0031397 negative regulation of protein ubiquitination IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA


Pathways (from Reactome)
Pathway description
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spoptm1d(KOMP)Mbp/Spoptm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N * FVB/N

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1ltm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057522 Spop / Q6ZWS8 / Mus musculus speckle-type POZ protein (Spop), transcript variant 2, mRNA. / O43791* / speckle type BTB/POZ protein*  / complex






 

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