ENSG00000144228


Homo sapiens

Features
Gene ID: ENSG00000144228
  
Biological name :SPOPL
  
Synonyms : Q6IQ16 / speckle type BTB/POZ protein like / SPOPL
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q22.1
Gene start: 138501801
Gene end: 138573547
  
Corresponding Affymetrix probe sets: 225658_at (Human Genome U133 Plus 2.0 Array)   225659_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000280098
Ensembl peptide - ENSP00000396006
Ensembl peptide - ENSP00000410201
NCBI entrez gene - 339745     See in Manteia.
RefSeq - XM_005263657
RefSeq - NM_001001664
RefSeq - XM_005263655
RefSeq - XM_005263656
RefSeq Peptide - NP_001001664
swissprot - Q6IQ16
swissprot - F8WD02
swissprot - F8WBB7
Ensembl - ENSG00000144228
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5BL35ENSDARG00000010563Danio rerio
 SPOPLENSGALG00000012380Gallus gallus
 SpoplENSMUSG00000026771Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPOP / O43791 / speckle type BTB/POZ proteinENSG0000012106780
KBTBD4 / Q9NVX7 / kelch repeat and BTB domain containing 4ENSG0000012344414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR034089  SPOP, C-terminal BACK-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030162 regulation of proteolysis IBA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA


Pathways (from Reactome)
Pathway description
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121067 SPOP / O43791 / speckle type BTB/POZ protein  / complex






 

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