ENSG00000121067


Homo sapiens

Features
Gene ID: ENSG00000121067
  
Biological name :SPOP
  
Synonyms : O43791 / speckle type BTB/POZ protein / SPOP
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.33
Gene start: 49598884
Gene end: 49678234
  
Corresponding Affymetrix probe sets: 204640_s_at (Human Genome U133 Plus 2.0 Array)   208927_at (Human Genome U133 Plus 2.0 Array)   238923_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423076
Ensembl peptide - ENSP00000422609
Ensembl peptide - ENSP00000423284
Ensembl peptide - ENSP00000427419
Ensembl peptide - ENSP00000426986
Ensembl peptide - ENSP00000426537
Ensembl peptide - ENSP00000426262
Ensembl peptide - ENSP00000425905
Ensembl peptide - ENSP00000425604
Ensembl peptide - ENSP00000425410
Ensembl peptide - ENSP00000424119
Ensembl peptide - ENSP00000240327
Ensembl peptide - ENSP00000377001
Ensembl peptide - ENSP00000420908
Ensembl peptide - ENSP00000420960
NCBI entrez gene - 8405     See in Manteia.
OMIM - 602650
RefSeq - NM_003563
RefSeq - NM_001007226
RefSeq - NM_001007227
RefSeq - NM_001007228
RefSeq - NM_001007229
RefSeq - NM_001007230
RefSeq - XM_005257723
RefSeq - XM_005257724
RefSeq - XM_017025204
RefSeq Peptide - NP_001007229
RefSeq Peptide - NP_001007230
RefSeq Peptide - NP_001007227
RefSeq Peptide - NP_001007228
RefSeq Peptide - NP_001007231
RefSeq Peptide - NP_003554
swissprot - D6RDV6
swissprot - D6RDG8
swissprot - D6RD94
swissprot - D6RBR3
swissprot - H0Y977
swissprot - D6RBH6
swissprot - O43791
swissprot - D6RA79
swissprot - D6RIS7
swissprot - D6RGZ4
swissprot - D6RFL7
Ensembl - ENSG00000121067
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spopENSDARG00000100519Danio rerio
 SPOPENSGALG00000009939Gallus gallus
 SpopENSMUSG00000057522Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPOPL / Q6IQ16 / speckle type BTB/POZ protein likeENSG0000014422884
KBTBD4 / Q9NVX7 / kelch repeat and BTB domain containing 4ENSG0000012344415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR034089  SPOP, C-terminal BACK-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030162 regulation of proteolysis IBA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:2000676 positive regulation of type B pancreatic cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IDA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000036257 CUL3 / Q13618 / cullin 3  / complex
 ENSG00000144228 SPOPL / Q6IQ16 / speckle type BTB/POZ protein like  / complex
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / reaction / complex
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / complex / reaction
 ENSG00000121067 SPOP / O43791 / speckle type BTB/POZ protein  / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex






 

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contact: otassy@igbmc.fr