ENSG00000173163


Homo sapiens

Features
Gene ID: ENSG00000173163
  
Biological name :COMMD1
  
Synonyms : COMMD1 / copper metabolism domain containing 1 / Q8N668
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p15
Gene start: 61888724
Gene end: 62147247
  
Corresponding Affymetrix probe sets: 226024_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413207
Ensembl peptide - ENSP00000410050
Ensembl peptide - ENSP00000416997
Ensembl peptide - ENSP00000308236
Ensembl peptide - ENSP00000398727
Ensembl peptide - ENSP00000401236
NCBI entrez gene - 150684     See in Manteia.
OMIM - 607238
RefSeq - XM_017003412
RefSeq - NM_001321781
RefSeq - NM_001321782
RefSeq - NM_152516
RefSeq Peptide - NP_689729
RefSeq Peptide - NP_001308710
RefSeq Peptide - NP_001308711
swissprot - H7C169
swissprot - H7C377
swissprot - H0Y7J4
swissprot - Q8N668
swissprot - E9PE85
Ensembl - ENSG00000173163
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 commd1ENSDARG00000031203Danio rerio
 COMMD1ENSGALG00000008931Gallus gallus
 Commd1ENSMUSG00000051355Mus musculus
 Gm28048ENSMUSG00000098650Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR017920  COMM domain
 IPR033776  COMMD1 N-terminal domain
 IPR037351  COMM domain-containing protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006893 Golgi to plasma membrane transport IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0048227 plasma membrane to endosome transport IDA
 biological_processGO:0055070 copper ion homeostasis IDA
 biological_processGO:1902306 negative regulation of sodium ion transmembrane transport IMP
 biological_processGO:2000009 negative regulation of protein localization to cell surface IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070300 phosphatidic acid binding IDA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000130725 UBE2M / P61081 / ubiquitin conjugating enzyme E2 M  / reaction / complex
 ENSG00000129559 NEDD8 / Q15843 / neural precursor cell expressed, developmentally down-regulated 8  / complex / reaction
 ENSG00000036257 CUL3 / Q13618 / cullin 3  / reaction / complex
 ENSG00000043093 Q96GG9 / DCUN1D1 / defective in cullin neddylation 1 domain containing 1  / complex / reaction
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / reaction / complex
 ENSG00000184182 UBE2F / Q969M7 / ubiquitin conjugating enzyme E2 F (putative)  / reaction / complex
 ENSG00000111530 CAND1 / Q86VP6 / cullin associated and neddylation dissociated 1  / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / reaction / complex
 ENSG00000188215 Q8IWE4 / DCUN1D3 / defective in cullin neddylation 1 domain containing 3  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / reaction / complex
 ENSG00000121022 COPS5 / Q92905 / COP9 signalosome subunit 5  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr