ENSG00000188215


Homo sapiens

Features
Gene ID: ENSG00000188215
  
Biological name :DCUN1D3
  
Synonyms : DCUN1D3 / defective in cullin neddylation 1 domain containing 3 / Q8IWE4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p12.3
Gene start: 20854925
Gene end: 20900384
  
Corresponding Affymetrix probe sets: 227333_at (Human Genome U133 Plus 2.0 Array)   239648_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454762
Ensembl peptide - ENSP00000319482
NCBI entrez gene - 123879     See in Manteia.
OMIM - 616167
RefSeq - NM_173475
RefSeq Peptide - NP_775746
swissprot - Q8IWE4
Ensembl - ENSG00000188215
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dcun1d3ENSDARG00000011493Danio rerio
 DCUN1D3ENSGALG00000002267Gallus gallus
 Q8K0V2ENSMUSG00000048787Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6PH85 / DCUN1D2 / defective in cullin neddylation 1 domain containing 2ENSG0000015040133
Q92564 / DCUN1D4 / defective in cullin neddylation 1 domain containing 4ENSG0000010918425
Q9BTE7 / DCUN1D5 / defective in cullin neddylation 1 domain containing 5ENSG0000013769222


Protein motifs (from Interpro)
Interpro ID Name
 IPR005176  Potentiating neddylation domain
 IPR014764  Defective-in-cullin neddylation protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010225 response to UV-C IDA
 biological_processGO:0010332 response to gamma radiation IDA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045116 protein neddylation IBA
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IBA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031624 ubiquitin conjugating enzyme binding IBA
 molecular_functionGO:0032182 ubiquitin-like protein binding IBA
 molecular_functionGO:0097602 cullin family protein binding IBA


Pathways (from Reactome)
Pathway description
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / reaction / complex
 ENSG00000173163 COMMD1 / Q8N668 / copper metabolism domain containing 1  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000101997 CCDC22 / O60826 / coiled-coil domain containing 22  / reaction / complex






 

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