ENSG00000143476


Homo sapiens

Features
Gene ID: ENSG00000143476
  
Biological name :DTL
  
Synonyms : denticleless E3 ubiquitin protein ligase homolog / DTL / Q9NZJ0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.3
Gene start: 212035553
Gene end: 212107400
  
Corresponding Affymetrix probe sets: 218585_s_at (Human Genome U133 Plus 2.0 Array)   222680_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355958
Ensembl peptide - ENSP00000443870
NCBI entrez gene - 51514     See in Manteia.
OMIM - 610617
RefSeq - XM_011509614
RefSeq - NM_001286229
RefSeq - NM_001286230
RefSeq - NM_016448
RefSeq Peptide - NP_001273158
RefSeq Peptide - NP_001273159
RefSeq Peptide - NP_057532
swissprot - Q9NZJ0
swissprot - F5GZ90
Ensembl - ENSG00000143476
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtlENSDARG00000023002Danio rerio
 DTLENSGALG00000009837Gallus gallus
 DtlENSMUSG00000037474Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006513 protein monoubiquitination IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0009411 response to UV IDA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019985 translesion synthesis IDA
 biological_processGO:0042769 DNA damage response, detection of DNA damage TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IMP
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106399 RPA3 / P35244 / replication protein A3  / complex / reaction
 ENSG00000106628 POLD2 / P49005 / DNA polymerase delta 2, accessory subunit  / reaction / complex
 ENSG00000077514 POLD3 / Q15054 / DNA polymerase delta 3, accessory subunit  / complex / reaction
 ENSG00000132383 RPA1 / P27694 / replication protein A1  / complex / reaction
 ENSG00000175482 POLD4 / Q9HCU8 / DNA polymerase delta 4, accessory subunit  / reaction / complex
 ENSG00000117748 RPA2 / P15927 / replication protein A2  / complex / reaction
 ENSG00000167986 DDB1 / Q16531 / damage specific DNA binding protein 1  / complex
 ENSG00000158290 CUL4B / Q13620 / cullin 4B  / complex
 ENSG00000139842 CUL4A / Q13619 / cullin 4A  / complex
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex
 ENSG00000132646 PCNA / P12004 / proliferating cell nuclear antigen  / reaction / complex
 ENSG00000062822 POLD1 / P28340 / DNA polymerase delta 1, catalytic subunit  / complex / reaction






 

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