ENSDARG00000013965


Danio rerio

Features
Gene ID: ENSDARG00000013965
  
Biological name :cul2
  
Synonyms : cul2 / cullin 2
  
Possible biological names infered from orthology : Q13617 / Q9D4H8
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 2283959
Gene end: 2343366
  
Corresponding Affymetrix probe sets: Dr.6194.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000114274
Ensembl peptide - ENSDARP00000143406
Ensembl peptide - ENSDARP00000123380
NCBI entrez gene - 336088     See in Manteia.
swissprot - E9QCA9
swissprot - E9QBK5
swissprot - A0A286Y8D7
ZFIN ID - ZDB-GENE-030131-8032
Ensembl - ENSDARG00000013965
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CUL2ENSGALG00000007095Gallus gallus
 CUL2ENSG00000108094Homo sapiens
 Cul2ENSMUSG00000024231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000001923938
cul1b / cullin 1b / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*ENSDARG0000000769138
cul3a / cullin 3a / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000003896728
cul5b / cullin 5b / CUL5* / Q93034* / cullin 5*ENSDARG0000000426028
cul4b / cullin 4B / A2A432* / Q13620*ENSDARG0000006051028
cul3b / cullin 3b / CUL3* / Q13618* / Q9JLV5* / cullin 3*ENSDARG0000010010827
cul5a / cullin 5a / CUL5* / Q93034* / cullin 5*ENSDARG0000006974227
cul4a / cullin 4A / Q13619* / Q3TCH7*ENSDARG0000009657821


Protein motifs (from Interpro)
Interpro ID Name
 IPR001373  Cullin, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain
 IPR016157  Cullin, conserved site
 IPR016158  Cullin homology domain
 IPR016159  Cullin repeat-like-containing domain superfamily
 IPR019559  Cullin protein, neddylation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0031461 cullin-RING ubiquitin ligase complex IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001285 intersegmental vessel intersegmental vessel aplastic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008697 epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction / complex
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / complex / reaction
 ENSDARG00000038576 ube2d1b / ubiquitin-conjugating enzyme E2D 1b / UBE2D1* / P51668* / P61080* / ubiquitin conjugating enzyme E2 D1*  / reaction
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction / complex
 ENSDARG00000043484 ube2d2 / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) / P62838* / P62837* / Ube2d2a* / ubiquitin conjugating enzyme E2 D2* / ubiquitin-conjugating enzyme E2D 2A*  / reaction
 ENSDARG00000057671 epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction / complex
 ENSDARG00000004632 egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / complex
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / complex
 ENSDARG00000038996 egln1a / egl-9 family hypoxia-inducible factor 1a / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / complex
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / complex
 ENSDARG00000100826 hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*  / reaction / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000007989 nedd8 / neural precursor cell expressed, developmentally down-regulated 8 / P29595* / Q15843*  / complex






 

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