ENSDARG00000038576


Danio rerio

Features
Gene ID: ENSDARG00000038576
  
Biological name :ube2d1b
  
Synonyms : ube2d1b / ubiquitin-conjugating enzyme E2D 1b
  
Possible biological names infered from orthology : P51668 / P61080 / UBE2D1 / ubiquitin conjugating enzyme E2 D1
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 7237666
Gene end: 7253270
  
Corresponding Affymetrix probe sets: Dr.12853.1.A1_at (Zebrafish Array)   NM_199664_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000033537
NCBI entrez gene - 324015     See in Manteia.
RefSeq - NM_199664
RefSeq Peptide - NP_955958
swissprot - Q6PC58
ZFIN ID - ZDB-GENE-030131-2735
Ensembl - ENSDARG00000038576
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBE2D1ENSGALG00000021213Gallus gallus
 P51668ENSG00000072401Homo sapiens
 P61080ENSMUSG00000019927Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ube2d1a / ubiquitin-conjugating enzyme E2D 1aENSDARG0000002910797
ube2d4 / ubiquitin-conjugating enzyme E2D 4 (putative) / Q9Y2X8*ENSDARG0000001505795
ube2d2l / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), likeENSDARG0000009974993
ube2d2 / ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) / P62838* / P62837* / Ube2d2a* / ubiquitin conjugating enzyme E2 D2* / ubiquitin-conjugating enzyme E2D 2A*ENSDARG0000004348492
ube2d3 / ubiquitin-conjugating enzyme E2D 3ENSDARG0000003847390
ube2e2 / ubiquitin-conjugating enzyme E2E 2 / Q91W82* / Q96LR5* / UBE2E1* / P52482* / P51965* / ubiquitin conjugating enzyme E2 E1*ENSDARG0000003467061
ube2e3 / ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) / P52483* / Q969T4* / ubiquitin conjugating enzyme E2 E3*ENSDARG0000001224461
rpl15 / ube2e1 / ubiquitin-conjugating enzyme E2E 1 / Q96LR5* / P51965* / UBE2E2* / ubiquitin conjugating enzyme E2 E2*ENSDARG0000011664961
ube2l3a / ubiquitin-conjugating enzyme E2L 3a / UBE2L5* / P68036* / UBE2L3* / ubiquitin conjugating enzyme E2 L3* / ubiquitin conjugating enzyme E2 L5*ENSDARG0000011208738
ube2l3b / ubiquitin-conjugating enzyme E2L 3b / UBE2L3* / P68036* / P68037* / UBE2L5* / ubiquitin conjugating enzyme E2 L3* / ubiquitin conjugating enzyme E2 L5*ENSDARG0000002714137
ube2s / Q4V908 / ubiquitin-conjugating enzyme E2S / Q16763* / Q921J4*ENSDARG0000003177534


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0031398 positive regulation of protein ubiquitination ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011462 otub1b / OTU deubiquitinase, ubiquitin aldehyde binding 1b / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex / reaction
 ENSDARG00000071037 pex13 / peroxisomal biogenesis factor 13 / Q92968* / Q9D0K1* / Peroxisomal membrane protein PEX13 *  / reaction / complex
 ENSDARG00000008697 epas1a / endothelial PAS domain protein 1a / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction
 ENSDARG00000034293 hif1ab / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000035149 pex12 / peroxisomal biogenesis factor 12 / O00623* / Q8VC48* / Peroxisome assembly protein 12 *  / reaction / complex
 ENSDARG00000041511 pex10 / peroxisomal biogenesis factor 10 / B1AUE5* / O60683* / Peroxisome biosis factor 10 *  / complex / reaction
 ENSDARG00000028322 pex14 / peroxisomal biogenesis factor 14 / O75381* / Q9R0A0* / Peroxisomal membrane protein PEX14 *  / complex / reaction
 ENSDARG00000006181 hif1aa / hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) a / HIF1A* / Q61221* / Q16665* / Hypoxia-inducible factor 1-alpha * / hypoxia inducible fact...  / reaction
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction
 ENSDARG00000038996 egln1a / egl-9 family hypoxia-inducible factor 1a / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / reaction
 ENSDARG00000057671 epas1b / endothelial PAS domain protein 1b / EPAS1* / Q99814* / P97481* / endothelial PAS domain protein 1* / Endothelial PAS domain-containing protein 1 *  / reaction
 ENSDARG00000070654 pex5 / peroxisomal biogenesis factor 5 / O09012* / P50542* / Peroxisomal targeting signal 1 receptor *  / complex / reaction
 ENSDARG00000013965 cul2 / cullin 2 / Q13617* / Q9D4H8*  / reaction
 ENSDARG00000004632 egln1b / egl-9 family hypoxia-inducible factor 1b / EGLN1* / Q91YE3* / Q9GZT9* / Egl nine homolog 1 * / egl-9 family hypoxia inducible factor 1*  / reaction
 ENSDARG00000062421 pex2 / peroxisomal biogenesis factor 2 / P28328*  / reaction / complex
 ENSDARG00000100826 hif1al / hypoxia-inducible factor 1, alpha subunit, like / HIF3A* / Q9Y2N7* / Q0VBL6* / Hypoxia-inducible factor 3-alpha * / hypoxia inducible factor 3 alpha subunit*  / reaction
 ENSDARG00000045359 elocb / elongin C paralog b / ELOC* / P83940* / Q15369* / elongin C*  / reaction
 ENSDARG00000037980 elob / elongin B / Elobl* / P62869* / Q15370*  / reaction
 ENSDARG00000023958 rnf181 / Q7ZW78 / ring finger protein 181 / Q9CY62* / Q9P0P0* / Mus musculus ring finger protein 181 (Rnf181), transcript variant 11, mRNA.*  / reaction / complex
 ENSDARG00000055536 otub1a / OTU deubiquitinase, ubiquitin aldehyde binding 1a / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex / reaction
 ENSDARG00000077130 bcl10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / reaction / complex






 

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