ENSGALG00000021213


Gallus gallus

Features
Gene ID: ENSGALG00000021213
  
Biological name :UBE2D1
  
Synonyms : UBE2D1 / ubiquitin conjugating enzyme E2 D1
  
Possible biological names infered from orthology : P51668 / P61080
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 5222460
Gene end: 5238309
  
Corresponding Affymetrix probe sets: Gga.13287.1.S1_at (Chicken Array)   Gga.13287.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000033525
Ensembl peptide - ENSGALP00000054470
Ensembl peptide - ENSGALP00000047567
NCBI entrez gene - 423641     See in Manteia.
RefSeq - NM_001199526
RefSeq - XM_015288010
RefSeq - XM_015288011
RefSeq Peptide - NP_001186455
swissprot - E1BZJ2
swissprot - A0A1D5PNM7
Ensembl - ENSGALG00000021213
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2d1bENSDARG00000038576Danio rerio
 P51668ENSG00000072401Homo sapiens
 P61080ENSMUSG00000019927Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2D2 / ubiquitin conjugating enzyme E2 D2 / P62838* / P62837* / Ube2d2a* / ubiquitin-conjugating enzyme E2D 2A*ENSGALG0000003812889
UBE2D3ENSGALG0000001231188
UBE2E3 / ubiquitin conjugating enzyme E2 E3 / P52483* / Q969T4*ENSGALG0000002079361
UBE2E1 / ubiquitin conjugating enzyme E2 E1 / P51965* / P52482*ENSGALG0000001128661
UBE2E2 / ubiquitin conjugating enzyme E2 E2 / Q91W82* / Q96LR5*ENSGALG0000003359361
UBE2L3 / P68037* / ubiquitin-conjugating enzyme E2L 3*ENSGALG0000003673939


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:1902916 positive regulation of protein polyubiquitination IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Signaling by BMP
Downstream TCR signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Ovarian tumor domain proteases
CDK-mediated phosphorylation and removal of Cdc6
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002151 PEX12 / peroxisomal biogenesis factor 12 / O00623* / Q8VC48* / Peroxisome assembly protein 12 *  / complex / reaction
 ENSGALG00000002836 PEX14 / peroxisomal biogenesis factor 14 / O75381* / Q9R0A0* / Peroxisomal membrane protein PEX14 *  / complex / reaction
 ENSGALG00000007832 PEX13 / peroxisomal biogenesis factor 13 / Q92968* / Q9D0K1* / Peroxisomal membrane protein PEX13 *  / reaction / complex
 ENSGALG00000010005 EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *  / reaction
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / reaction
 ENSGALG00000010001 EGLN3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / complex
 ENSGALG00000007095 CUL2 / cullin-2 / Q13617* / Q9D4H8*  / reaction
 ENSGALG00000013874 PEX7 / peroxisomal biogenesis factor 7 / O00628* / P97865* / Peroxisomal targeting signal 2 receptor *  / reaction / complex
 ENSGALG00000035752 PEX2 / peroxisomal biogenesis factor 2 / P28328*  / complex / reaction






 

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