ENSGALG00000028009


Gallus gallus

Features
Gene ID: ENSGALG00000028009
  
Biological name :
  
Synonyms :
  
Possible biological names infered from orthology : P40337 / P40338 / Q6RSH7 / VHL / VHLL / VHL like / von Hippel-Lindau tumor suppressor
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 19467559
Gene end: 19469193
  
Corresponding Affymetrix probe sets: GgaAffx.5294.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000043081
NCBI entrez gene - 416117     See in Manteia.
RefSeq - XM_414447
swissprot - R4GLJ6
Ensembl - ENSGALG00000028009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vhlENSDARG00000070617Danio rerio
 VHLENSG00000134086Homo sapiens
 VHLLENSG00000189030Homo sapiens
 VhlENSMUSG00000033933Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002714  von Hippel-Lindau tumour suppressor protein
 IPR022772  von Hippel-Lindau disease tumour suppressor, beta/alpha domain
 IPR024048  von Hippel-Lindau disease tumour suppressor, alpha domain
 IPR024053  von Hippel-Lindau disease tumour suppressor, beta domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0003309 type B pancreatic cell differentiation IEA
 biological_processGO:0003310 pancreatic A cell differentiation IEA
 biological_processGO:0006582 melanin metabolic process IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination IBA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0043534 blood vessel endothelial cell migration IEA
 biological_processGO:0045602 negative regulation of endothelial cell differentiation IEA
 biological_processGO:0048069 eye pigmentation IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0048877 homeostasis of number of retina cells IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0061072 iris morphogenesis IEA
 biological_processGO:0061073 ciliary body morphogenesis IEA
 biological_processGO:0070243 regulation of thymocyte apoptotic process IEA
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IEA
 biological_processGO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway IEA
 biological_processGO:1903827 regulation of cellular protein localization IEA
 biological_processGO:2001233 regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0030891 VCB complex IBA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007095 CUL2 / cullin-2 / Q13617* / Q9D4H8*  / complex
 ENSGALG00000021213 UBE2D1 / ubiquitin conjugating enzyme E2 D1 / P51668* / P61080*  / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000010005 EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction
 ENSGALG00000010001 EGLN3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex
 ENSGALG00000006428 UBE2I / P63283 / SUMO-conjugating enzyme UBC9 / P63280* / P63279* / ubiquitin conjugating enzyme E2 I*  / reaction
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000038128 UBE2D2 / ubiquitin conjugating enzyme E2 D2 / P62838* / P62837* / Ube2d2a* / ubiquitin-conjugating enzyme E2D 2A*  / reaction






 

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