ENSDARG00000070617


Danio rerio

Features
Gene ID: ENSDARG00000070617
  
Biological name :vhl
  
Synonyms : vhl / von Hippel-Lindau tumor suppressor
  
Possible biological names infered from orthology : P40337 / P40338 / Q6RSH7 / VHLL / VHL like
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 40451270
Gene end: 40455109
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000094654
NCBI entrez gene - 791202     See in Manteia.
RefSeq - NM_001080684
RefSeq Peptide - NP_001074153
swissprot - F1QY17
ZFIN ID - ZDB-GENE-070112-1042
Ensembl - ENSDARG00000070617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000028009Gallus gallus
 VHLENSG00000134086Homo sapiens
 VHLLENSG00000189030Homo sapiens
 VhlENSMUSG00000033933Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
vhll / von Hippel-Lindau tumor suppressor likeENSDARG0000007861327


Protein motifs (from Interpro)
Interpro ID Name
 IPR002714  von Hippel-Lindau tumour suppressor protein
 IPR022772  von Hippel-Lindau disease tumour suppressor, beta/alpha domain
 IPR024048  von Hippel-Lindau disease tumour suppressor, alpha domain
 IPR024053  von Hippel-Lindau disease tumour suppressor, beta domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0016567 protein ubiquitination IBA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0039022 pronephric duct development IMP
 biological_processGO:0043576 regulation of respiratory gaseous exchange IMP
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0030891 VCB complex IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood increased accumulation yolk , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta dilated , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0000099 brain vasculature brain vasculature morphology , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
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 ZFA:0000150 pronephric duct pronephric duct curved , abnormal
pronephric duct cystic , abnormal
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 ZFA:0000151 pronephros pronephros decreased functionality , abnormal
pronephros shape , abnormal
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 ZFA:0000152 retina retina edematous , abnormal
retina deformed , abnormal
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 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta dilated , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein vascular sprouts increased amount , abnormal
intersegmental vein vascular sprouts increased amount , exacerbated
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 ZFA:0001061 intersegmental artery intersegmental artery vascular sprouts increased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism decreased life span , ameliorated
whole organism viability , abnormal
whole organism increased amount , abnormal
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 ZFA:0001114 head head increased amount , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel branched , abnormal
intersegmental vessel increased size , abnormal
intersegmental vessel dorsal region increased branchiness , abnormal
intersegmental vessel dorsal region branchiness , exacerbated
intersegmental vessel vascular sprouts increased amount , abnormal
intersegmental vessel vascular sprouts increased amount , exacerbated
intersegmental vessel vascular sprouts displaced to neural tube , abnormal
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 ZFA:0001329 retinal inner plexiform layer retinal inner plexiform layer ocular blood vessel mislocalised , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus disorganized , abnormal
pronephric glomerulus bicellular tight junction decreased amount , abnormal
pronephric glomerulus increased size , abnormal
pronephric glomerulus atrophied , abnormal
pronephric glomerulus cystic , abnormal
pronephric glomerulus swollen , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule curved , abnormal
pronephric tubule distended , abnormal
pronephric tubule cystic , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule diameter , ameliorated
pronephric proximal convoluted tubule increased diameter , abnormal
pronephric proximal convoluted tubule apical-basal polarity , abnormal
pronephric proximal convoluted tubule cytoplasmic vesicle amount , ameliorated
pronephric proximal convoluted tubule cytoplasmic vesicle increased amount , abnormal
pronephric proximal convoluted tubule epithelial cell decreased amount , abnormal
pronephric proximal convoluted tubule ciliated epithelial cell disorganized , abnormal
pronephric proximal convoluted tubule ciliated epithelial cell organization quality , ameliorated
pronephric proximal convoluted tubule cell proliferation increased occurrence , abnormal
pronephric proximal convoluted tubule apoptotic process increased occurrence , abnormal
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 ZFA:0001621 pronephric proximal straight tubule pronephric proximal straight tubule diameter , ameliorated
pronephric proximal straight tubule increased diameter , abnormal
pronephric proximal straight tubule apical-basal polarity , abnormal
pronephric proximal straight tubule cytoplasmic vesicle amount , ameliorated
pronephric proximal straight tubule cytoplasmic vesicle increased amount , abnormal
pronephric proximal straight tubule epithelial cell decreased amount , abnormal
pronephric proximal straight tubule ciliated epithelial cell disorganized , abnormal
pronephric proximal straight tubule ciliated epithelial cell organization quality , ameliorated
pronephric proximal straight tubule cell proliferation increased occurrence , abnormal
pronephric proximal straight tubule apoptotic process increased occurrence , abnormal
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 ZFA:0001673 pronephric podocyte pronephric podocyte physical object quality , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature blood vessel increased amount , abnormal
trunk vasculature morphology , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel morphology , abnormal
dorsal longitudinal anastomotic vessel increased size , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell increased amount , abnormal
ventral wall of dorsal aorta hematopoietic stem cell amount , ameliorated
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 ZFA:0005035 subintestinal vein subintestinal vein spatial pattern , abnormal
subintestinal vein increased branchiness , abnormal
subintestinal vein sprouting angiogenesis increased occurrence , abnormal
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 ZFA:0005044 optic artery optic artery increased permeability , abnormal
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 ZFA:0005046 hyaloid vessel hyaloid vessel branched , abnormal
hyaloid vessel malformed , abnormal
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 ZFA:0005094 optic choroid vascular plexus optic choroid vascular plexus branched , abnormal
optic choroid vascular plexus malformed , abnormal
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 ZFA:0005297 cranial blood vessel cranial blood vessel increased amount , abnormal
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 ZFA:0005314 blood vessel blood vessel increased diameter , abnormal
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 ZFA:0007057 ocular blood vessel ocular blood vessel branched , abnormal
ocular blood vessel malformed , abnormal
ocular blood vessel morphology , abnormal
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 ZFA:0009014 hematopoietic stem cell hematopoietic stem cell increased amount , abnormal
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 ZFA:0009141 macrophage macrophage increased amount , abnormal
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 ZFA:0009248 neuron neuron increased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased amount , abnormal
nucleate erythrocyte optical quality , abnormal
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 ZFA:0009285 podocyte podocyte increased amount , abnormal
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 ZFA:0009354 hematopoietic multipotent progenitor cell hematopoietic multipotent progenitor cell increased amount , abnormal
hematopoietic multipotent progenitor cell decreased amount , ameliorated
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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